ALPL anticorps

N° du produit ABIN969500

L’anticorps Souris Monoclonal anti-ALPL a été validé pour WB, ELISA, IHC et FACS. Il convient pour détecter ALPL dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour ALPL anticorps (ABIN969500)

Antigène: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ALPL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 2F4

Détail du produit anti-ALPL anticorps

Fonction: ALPL Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ALPL expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ALPL (ABIN969500)

Kannampuzha, Tupy, Pritzker: "Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution." dans: The Journal of rheumatology, Vol. 36, Issue 12, pp. 2758-65, (2009) (PubMed).

Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes." dans: Calcified tissue international, Vol. 85, Issue 3, pp. 228-34, (2009) (PubMed).

Détails sur ALPL

Antigène: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Autre désignation: ALPL

Sujet: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Poids moléculaire: 57.3 kDa

ID gène: 249

UniProt: P05186