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APPL2 Produits

(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))

Catégories

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].

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Catégories APPL2 en vedette

APPL2 Anticorps

High quality antibodies with extensive validation data.

APPL2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

APPL2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
N° du produit ABIN527415
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (3)
N° du produit ABIN527414
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
N° du produit ABIN7149505
Quantité 100 μg
Fiche technique Fiche technique

APPL2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964611
Quantité 96 tests
Fiche technique Fiche technique

APPL2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7121696
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1345412
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1345410
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits APPL2

Gaspar, Muñoz, Kuga, Nakandakari, Crisol, Lenhare, Breda, Botezelli, SantAna, da Silva, Cintra, de Moura, Ropelle, Pauli: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." dans: The European journal of neuroscience, (2019) (PubMed).

Canciglieri, Kuga, Muñoz, Gaspar, da Rocha, Breda, Anaruma, Minuzzi, da Silva, Cintra, de Moura, Ropelle, Pauli: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." dans: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).

Gaspar, Muñoz, Formigari, Kuga, Nakandakari, Botezelli, da Silva, Cintra, de Moura, Ropelle, Pauli: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." dans: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).

Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." dans: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).

Synonymes et noms alternatifs relatifs à APPL2

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2), APPL2, Dip3b, dip13b, DIP13B, MGC84621, RGD1563028

Protein level used designations for APPL2

  • DCC-interacting protein 13-beta
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • amyloid beta (A4) precursor-like protein 2
  • DIP13 beta
  • adapter protein containing PH domain, PTB domain and leucine zipper motif 2
  • Dip3 beta
  • dip13-beta
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