Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Jul 2008].
AZU1
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos Azurocidin Protéines
Mayer, Dinkic, Jesenofsky, Klauss, Schirmacher, Dapunt, Hackert, Uhle, Hänsch, Gaida: "Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging." dans: Theranostics, Vol. 8, Issue 1, pp. 13-30, (2017) (PubMed).
Wang, Liu, Dong, Pan, Ma: "Azurocidin-induced inhibition of oxygen metabolism in mitochondria is antagonized by heparin." dans: Experimental and therapeutic medicine, Vol. 8, Issue 5, pp. 1473-1478, (2014) (PubMed).