BIN1 Produits
(Bridging Integrator 1 (BIN1))
Catégories
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011].
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Catégories BIN1 en vedette
BIN1 Anticorps
High quality antibodies with extensive validation data.
BIN1 Kits ELISA
Reliable ELISA kits for a wide range of species.
BIN1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BIN1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Rat
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN7259755
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (5)
N° du produit
ABIN5542281
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, ICC, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN2855595
Quantité
100 μL
Fiche technique
Fiche technique
BIN1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954195
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6201968
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6201967
Quantité
96 tests
Fiche technique
Fiche technique
BIN1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
N° du produit
ABIN2715270
Quantité
20 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN667182
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346679
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BIN1
: "Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment." dans: Molecular medicine (Cambridge, Mass.), Vol. 25, Issue 1, pp. 53, (2020) (PubMed).: "FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis." dans: Nature cell biology, Vol. 20, Issue 9, pp. 1023-1031, (2019) (PubMed).
: "Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain." dans: Acta neuropathologica communications, Vol. 3, pp. 58, (2015) (PubMed).
: "Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology." dans: Journal of Alzheimer's disease : JAD, Vol. 42, Issue 4, pp. 1221-7, (2014) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." dans: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy." dans: Nature genetics, Vol. 39, Issue 9, pp. 1134-9, (2007) (PubMed).
: "Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival." dans: Cancer biology & therapy, Vol. 6, Issue 2, pp. 192-4, (2007) (PubMed).
: "Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication." dans: The Journal of biological chemistry, Vol. 282, Issue 19, pp. 14608-15, (2007) (PubMed).
: "A role for the putative tumor suppressor Bin1 in muscle cell differentiation." dans: Molecular and cellular biology, Vol. 18, Issue 1, pp. 566-75, (1998) (PubMed).
: "Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing." dans: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31453-8, (1998) (PubMed).
Synonymes et noms alternatifs relatifs à BIN1
bridging integrator 1 (BIN1), bridging integrator 1 S homeolog (bin1.S), bridging integrator 1 (bin1), bridging integrator 1b (bin1b), bridging integrator 1 (Bin1), ALP-1, amph2, AMPH2, amphl, AMPHL, Amphl, bin1, BIN1, BRAMP-2, cb57, MGC53185, MGC76187, sh3p9, SH3P9, zgc:86701Protein level used designations for BIN1
- bridging integrator 1
- myc box-dependent-interacting protein 1-like
- amphiphysin II
- amphiphysin-like protein
- box dependant MYC interacting protein 1
- box-dependent myc-interacting protein 1
- myc box-dependent-interacting protein 1
- SH3 domain-containing protein 9
- amphiphysin 2
- myc box dependent interacting protein 1
- Amph2
- amphiphysin IIamph2
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