C5 Produits
(Complement Component 5 (C5))
Catégories
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008].
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Catégories C5 en vedette
C5 Anticorps
High quality antibodies with extensive validation data.
C5 Kits ELISA
Reliable ELISA kits for a wide range of species.
C5 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
C5 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (6)
N° du produit
ABIN3044294
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IF (p), IF (cc), IHC (p)
Validations
- (1)
- (3)
N° du produit
ABIN727875
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (1)
- (3)
N° du produit
ABIN652518
Quantité
400 μL
Fiche technique
Fiche technique
C5 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (1)
N° du produit
ABIN6955010
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966011
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966010
Quantité
96 tests
Fiche technique
Fiche technique
C5 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7274038
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1347565
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7320495
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits C5
: "Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency." dans: American journal of physiology. Endocrinology and metabolism, Vol. 317, Issue 2, pp. E200-E211, (2020) (PubMed).: "iTRAQ-Based Proteomic Analysis Reveals Protein Profile in Plasma from Children with Autism." dans: Proteomics. Clinical applications, Vol. 12, Issue 3, pp. e1700085, (2019) (PubMed).
: "SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway." dans: Theranostics, Vol. 7, Issue 6, pp. 1749-1769, (2018) (PubMed).
: "Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis." dans: Science immunology, Vol. 2, Issue 7, (2017) (PubMed).
: "Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression." dans: Cancer letters, Vol. 412, pp. 30-36, (2017) (PubMed).
: "Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components." dans: Molecular immunology, Vol. 76, pp. 13-21, (2017) (PubMed).
: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." dans: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).
: "The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura." dans: PLoS ONE, Vol. 10, Issue 3, pp. e0120411, (2015) (PubMed).
: "C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression." dans: Hepatology (Baltimore, Md.), Vol. 60, Issue 1, pp. 114-24, (2014) (PubMed).
: "Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice." dans: Nanotoxicology, Vol. 8, Issue 6, pp. 686-96, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à C5
complement C5 (C5), complement component 5 (c5), complement component 5 (C5), hemolytic complement (Hc), C5, C5a, C5b, CPAMD4, Hc, He, LOC565774, RGD1561905Protein level used designations for C5
- complement component 5
- similar to complement component C5-1
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
- C5a anaphylatoxin
- anaphylatoxin C5a analog
- complement C5
- prepro-C5
- anaphylatoxin
- complement component C5
- complement C5a anaphylatoxin
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