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CBFA2T2 Protéines

(Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].

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CBFA2T2 Protein (AA 1-594) (His tag)

custom-made CBFA2T2 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Cbfa2t2 Protein, UniprotID O70374

3 images

N° du produit ABIN7562544

Détails

CBFA2T2 Protein (AA 1-604) (His tag)

custom-made CBFA2T2 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant CBFA2T2 Protein, UniprotID O43439

3 images

N° du produit ABIN7554633

Détails

CBFA2T2 Protein (AA 1-614) (GST tag)

CBFA2T2 Origine: Humain Hôte: Wheat germ Recombinant ELISA, WB, AA, AP

Image no. 1 for Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 1-614) protein (GST tag) (ABIN1348157)

1 image

N° du produit ABIN1348157

Détails

CBFA2T2 Protein (AA 1-594) (Strep Tag)

custom-made CBFA2T2 Origine: Souris Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

N° du produit ABIN3131988

Détails

CBFA2T2 Protein (AA 1-604) (Strep Tag)

custom-made CBFA2T2 Origine: Humain Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

N° du produit ABIN3093949