CRBN Produits
(Cereblon (CRBN))
Catégories
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Catégories CRBN en vedette
CRBN Anticorps
High quality antibodies with extensive validation data.
CRBN Kits ELISA
Reliable ELISA kits for a wide range of species.
CRBN Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CRBN recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
N° du produit
ABIN7165198
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (3)
- (1)
N° du produit
ABIN526543
Quantité
50 μg
Fiche technique
Fiche technique
Application
WB
Validations
- (1)
N° du produit
ABIN6744097
Quantité
100 μL
Fiche technique
Fiche technique
CRBN recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965629
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954563
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954564
Quantité
96 tests
Fiche technique
Fiche technique
CRBN recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1350279
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122244
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122245
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CRBN
: "Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome." dans: eLife, Vol. 7, (2019) (PubMed).: "Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs." dans: Bioorganic & medicinal chemistry, Vol. 27, Issue 12, pp. 2466-2479, (2019) (PubMed).
: "Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations." dans: Nature communications, Vol. 10, Issue 1, pp. 3468, (2019) (PubMed).
: "Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of ..." dans: Journal of medicinal chemistry, (2018) (PubMed).
: "Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation." dans: Nature chemical biology, Vol. 14, Issue 2, pp. 163-170, (2018) (PubMed).
: "Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41." dans: Cancer research, Vol. 76, Issue 12, pp. 3531-40, (2016) (PubMed).
: "Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 20, pp. 6772-89, (2014) (PubMed).
: "CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis." dans: Nature communications, Vol. 5, pp. 3924, (2014) (PubMed).
: "Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity." dans: British journal of haematology, Vol. 164, Issue 2, pp. 233-44, (2014) (PubMed).
: "Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer." dans: Oncogene, Vol. 30, Issue 33, pp. 3570-84, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à CRBN
cereblon (crbn), cereblon (CRBN), ATP-dependent protease La (LON) domain protein (AT2G25740), cereblon (Crbn), 2610203G15Rik, 2900045O07Rik, AF229032, AW108261, F3N11.21, MRT2, mrt2a, MRT2A, piL, zgc:92404Protein level used designations for CRBN
- protein cereblon
- zcrbn
- cereblon
- protein cereblon-like
- protein x 0001
- novel lethal
- protein PiL
- Protein cereblon
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