DEFB103B Protéine
Protéine Recombinant DEFB103B exprimée dans Escherichia coli (E. coli).
N° du produit ABIN2017675
Aperçu rapide pour DEFB103B Protéine (ABIN2017675)
Antigène
DEFB103B
(Defensin, beta 103B (DEFB103B))
Type de proteíne
Recombinant
Activité biologique
Active
Origine
Souris
Source
Escherichia coli (E. coli)
Pureté
> 95 % by SDS-PAGE and HPLC analyses.
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Séquence
- KKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K
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Attributs du produit
- Fully biologically active when compared to standard. The ED50 as determined by anti-microbial activity against E.coli. is less than 20 μg/mL, corresponding to a specific activity of > 50 IU/mg.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- < 1 EU/μg of rMuBD-3 as determined by LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
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Buffer
- Lyophilized from a 0.2 μm filtered concentrated solution in 2 x PBS, pH 7.4.
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.
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- DEFB103B (Defensin, beta 103B (DEFB103B))
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Autre désignation
- beta Defensin-3(BD-3)
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Sujet
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Beta defensin-3, also known as BD-3 and DEFB-3, is a membrane active cationic peptide that functions in inflammation and innate immune responses and coded by Defb 3 gene on chromosome 8 in mouse. There are at least 30 beta-defensins which are distinguished from beta-defensins by the connectivity pattern of their three intramolecular disulfide bonds. BD3 is widely expressed among epithelial tissues, notably by keratinocytes and airway epithelial cells. It is upregulated in response to proinflammatory cytokines, microbial and viral infections, and at the edges of skin wounds. BD3 induction in osteoarthritis chondrocytes promotes MMP1 and 13 productions and inhibits TIMP1 and 2 expressions.
Synonyms: BD-3 Murine, BD 3 Murine -
Poids moléculaire
- 4.6 kDa, a single non-glycosylated polypeptide chain containing 41 amino acids.
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Pathways
- Production of Molecular Mediator of Immune Response
Antigène
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