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DNMT3A Produits

(DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Catégories

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Catégories DNMT3A en vedette

DNMT3A Anticorps

High quality antibodies with extensive validation data.

DNMT3A Kits ELISA

Reliable ELISA kits for a wide range of species.

DNMT3A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

DNMT3A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (10)
  • (5)
N° du produit ABIN387881
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IP
Validations
  • (3)
  • (7)
N° du produit ABIN3022834
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
  • (4)
N° du produit ABIN669336
Quantité 100 μL
Fiche technique Fiche technique

DNMT3A recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962647
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955416
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1884515
Quantité 96 tests
Fiche technique Fiche technique

DNMT3A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (2)
N° du produit ABIN2719617
Quantité 20 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122679
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1351868
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits DNMT3A

van Mierlo, Dirks, De Clerck, Brinkman, Huth, Kloet, Saksouk, Kroeze, Willems, Farlik, Bock, Jansen, Deforce, Vermeulen, Déjardin, Dhaenens, Marks: "Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency." dans: Cell stem cell, Vol. 24, Issue 1, pp. 123-137.e8, (2019) (PubMed).

Heyn, Logan, Fluteau, Challis, Auchynnikava, Martin, Marsh, Taglini, Kilanowski, Parry, Cormier-Daire, Fong, Gibson, Hwa, Ibáñez, Robertson, Sebastiani, Rappsilber, Allshire, Reijns, Dauber, Sproul et al.: "Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions. ..." dans: Nature genetics, Vol. 51, Issue 1, pp. 96-105, (2019) (PubMed).

Cyphert, Walker, Hang, Dhawan, Haliyur, Bonatakis, Avrahami, Brissova, Kaestner, Bhushan, Powers, Stein: "Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally." dans: Diabetes, Vol. 68, Issue 2, pp. 337-348, (2019) (PubMed).

Yang, Wu, Li, Gao, Yang, Li, Kong: "The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells." dans: Molecular carcinogenesis, (2018) (PubMed).

La, Mäkelä, Chan, Rossello, Nefzger, Legrand, De Seram, Polo, Hobbs: "Identification of dynamic undifferentiated cell states within the male germline." dans: Nature communications, Vol. 9, Issue 1, pp. 2819, (2018) (PubMed).

ODoherty, OShea, Sandra, Lonergan, Fair, Forde: "Imprinted and DNA methyltransferase gene expression in the endometrium during the pre- and peri-implantation period in cattle." dans: Reproduction, fertility, and development, Vol. 29, Issue 9, pp. 1729-1738, (2018) (PubMed).

Chatterjee, Lin, Chen, Peng, Wu, Tseng, Chen, Shen: "DNA Demethylation by DNMT3A and DNMT3B in vitro and of Methylated Episomal DNA in Transiently Transfected Cells." dans: Biochimica et biophysica acta. Gene regulatory mechanisms, Vol. 1861, Issue 11, pp. 1048-1061, (2018) (PubMed).

Pang, Liu, Li, Xiao, Wang, Yang, Li, Tang, Qin, Du, Zhang, Liu, Sun, Ren: "MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer." dans: Journal of cellular and molecular medicine, Vol. 22, Issue 12, pp. 6262-6274, (2018) (PubMed).

Neri, Rapelli, Krepelova, Incarnato, Parlato, Basile, Maldotti, Anselmi, Oliviero: "Intragenic DNA methylation prevents spurious transcription initiation." dans: Nature, Vol. 543, Issue 7643, pp. 72-77, (2017) (PubMed).

Acharya, Baddour, Kawashita, Allen, Syage, Nguyen, Yoon, Giedzinski, Yu, Parihar, Baulch: "Epigenetic determinants of space radiation-induced cognitive dysfunction." dans: Scientific reports, Vol. 7, pp. 42885, (2017) (PubMed).

Synonymes et noms alternatifs relatifs à DNMT3A

DNA methyltransferase 3 alpha (DNMT3A), DNA methyltransferase 3A (Dnmt3a), DNA methyltransferase 3 alpha (Dnmt3a), DNA methyltransferase 3 alpha (dnmt3a), DNA (cytosine-5-)-methyltransferase 3 alpha b (dnmt3ab), DNMT3A, dnmt3a1, DNMT3A2, dnmt6, M.HsaIIIA, MmuIIIA

Protein level used designations for DNMT3A

  • DNA (cytosine-5)-methyltransferase 3A
  • DNA cytosine methyltransferase 3 alpha
  • DNA (cytosine-5-)-methyltransferase 3 alpha
  • DNA MTase HsaIIIA
  • DNA cytosine methyltransferase 3A2
  • DNA methyltransferase 3A
  • DNA methyl transferase alpha
  • DNA-methyltransferase 3a
  • DNA MTase MmuIIIA
  • DNA methyltransferase MmuIIIA
  • LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A
  • DNA (cytosine-5-)-methyltransferase 6
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