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EPM2A Produits

(Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Catégories

This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

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Catégories EPM2A en vedette

EPM2A Anticorps

High quality antibodies with extensive validation data.

EPM2A Kits ELISA

Reliable ELISA kits for a wide range of species.

EPM2A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

EPM2A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (8)
  • (4)
N° du produit ABIN563505
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (4)
N° du produit ABIN2855883
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7157846
Quantité 100 μg
Fiche technique Fiche technique

EPM2A recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1139971
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1139969
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1139970
Quantité 96 tests
Fiche technique Fiche technique

EPM2A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1352959
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1352957
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3092377
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits EPM2A

Irimia, Tagliabracci, Meyer, Segvich, DePaoli-Roach, Roach: "Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice." dans: The Journal of biological chemistry, (2015) (PubMed).

Zhu, Zhang, Kelly, Cheng: "The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein-protein interactions." dans: Bioscience reports, Vol. 34, Issue 4, (2014) (PubMed).

Sherwood, Johnson, Delgado-Escueta, Gentry: "A bioassay for Lafora disease and laforin glucan phosphatase activity." dans: Clinical biochemistry, Vol. 46, Issue 18, pp. 1869-76, (2013) (PubMed).

DePaoli-Roach, Segvich, Meyer, Rahimi, Worby, Gentry, Roach: "Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity." dans: Human molecular genetics, Vol. 21, Issue 7, pp. 1604-10, (2012) (PubMed).

Tiberia, Turnbull, Wang, Ruggieri, Zhao, Pencea, Israelian, Wang, Ackerley, Wang, Liu, Minassian: "Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease." dans: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25650-9, (2012) (PubMed).

Turnbull, Girard, Lohi, Chan, Wang, Tiberia, Omer, Ahmed, Bennett, Chakrabarty, Tyagi, Liu, Pencea, Zhao, Scherer, Ackerley, Minassian: "Early-onset Lafora body disease." dans: Brain : a journal of neurology, Vol. 135, Issue Pt 9, pp. 2684-98, (2012) (PubMed).

Turnbull, Wang, Girard, Ruggieri, Wang, Draginov, Kameka, Pencea, Zhao, Ackerley, Minassian: "Glycogen hyperphosphorylation underlies lafora body formation." dans: Annals of neurology, Vol. 68, Issue 6, pp. 925-33, (2011) (PubMed).

Tagliabracci, Turnbull, Wang, Girard, Zhao, Skurat, Delgado-Escueta, Minassian, Depaoli-Roach, Roach: "Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 49, pp. 19262-6, (2007) (PubMed).

Mittal, Dubey, Yamakawa, Ganesh: "Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment." dans: Human molecular genetics, Vol. 16, Issue 7, pp. 753-62, (2007) (PubMed).

Wang, Parker, Skurat, Raben, DePaoli-Roach, Roach: "Relationship between glycogen accumulation and the laforin dual specificity phosphatase." dans: Biochemical and biophysical research communications, Vol. 350, Issue 3, pp. 588-92, (2006) (PubMed).

Synonymes et noms alternatifs relatifs à EPM2A

EPM2A, laforin glucan phosphatase (EPM2A), epilepsy, progressive myoclonic epilepsy, type 2 gene alpha (Epm2a), EPM2A, laforin glucan phosphatase (Epm2a), EPM2, laforin, MELF, Tg(TcraK,TcrbK)TG-BFlv, TG-B

Protein level used designations for EPM2A

  • laforin
  • LAFPTPase
  • lafora PTPase
  • epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
  • epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
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