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FBXO4 Produits

(F-Box Protein 4 (FBXO4))

Catégories

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].

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Catégories FBXO4 en vedette

FBXO4 Anticorps

High quality antibodies with extensive validation data.

FBXO4 Kits ELISA

Reliable ELISA kits for a wide range of species.

FBXO4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

FBXO4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IP, IHC
Validations
  • (4)
N° du produit ABIN7152437
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IP
Validations
  • (3)
N° du produit ABIN525677
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7152439
Quantité 100 μg
Fiche technique Fiche technique

FBXO4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Sheep
Analytical Method
Validations
N° du produit ABIN1774002
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN1743097
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Dog
Analytical Method
Validations
N° du produit ABIN1769106
Quantité 96 tests
Fiche technique Fiche technique

FBXO4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353823
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
N° du produit ABIN3079809
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
N° du produit ABIN3126035
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits FBXO4

Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." dans: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).

Yonekawa, Yang, Counter: "PinX1 localizes to telomeres and stabilizes TRF1 at mitosis." dans: Molecular and cellular biology, Vol. 32, Issue 8, pp. 1387-95, (2012) (PubMed).

Barbash, Lee, Diehl: "Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ" dans: Oncogene, (2011) (PubMed).

Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: "Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability." dans: Molecular and cellular biology, Vol. 28, Issue 23, pp. 7245-58, (2008) (PubMed).

Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: "Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer." dans: Cancer cell, Vol. 14, Issue 1, pp. 68-78, (2008) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Lee, Perrem, Harper, Lu, Zhou: "The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance." dans: The Journal of biological chemistry, Vol. 281, Issue 2, pp. 759-68, (2006) (PubMed).

Lin, Barbash, Kumar, Weber, Harper, Klein-Szanto, Rustgi, Fuchs, Diehl: "Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex." dans: Molecular cell, Vol. 24, Issue 3, pp. 355-66, (2006) (PubMed).

den Engelsman, Keijsers, de Jong, Boelens: "The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination." dans: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4699-704, (2003) (PubMed).

Kennedy, Mohler, Shanebeck, Baum, Picha, Otten-Evans, Janeway, Grabstein: "Induction of B cell costimulatory function by recombinant murine CD40 ligand." dans: European journal of immunology, Vol. 24, Issue 1, pp. 116-23, (1994) (PubMed).

Synonymes et noms alternatifs relatifs à FBXO4

F-box protein 4 (FBXO4), F-box protein 4 (Fbxo4), F-box protein 4 (fbxo4), F-box protein 4 L homeolog (fbxo4.L), 1700096C12Rik, AI851261, AW494535, FBX4, Fbx4, fbx4, FBXO4, si:dkey-46a10.2

Protein level used designations for FBXO4

  • F-box only protein 4
  • F-box protein Fbx4
  • F-box protein 4
  • F-box only protein 4-like
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