The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008].
Åström-Olsson, Li, Olofsson, Borén, Öhlin, Grip: "Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics." dans: Biochemical and biophysical research communications, Vol. 422, Issue 4, pp. 732-8, (2012) (PubMed).
Pseudonymes pour FKBP1B Protéines
FK506 binding protein 1B (FKBP1B) Protéines FK506 binding protein 1B L homeolog (fkbp1b.L) Protéines FK506 binding protein 1B (fkbp1b) Protéines FK506 binding protein 1b (Fkbp1b) Protéines FK506 binding protein 1B (Fkbp1b) Protéines 12.6kDa Protéines AW494148 Protéines calstabin2 Protéines DKFZp459K1429 Protéines FKBP1B Protéines FKBP1L Protéines FKBP12.6 Protéines MGC68829 Protéines OTK4 Protéines PKBP1L Protéines PPIase Protéines