Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008].
Dernières publications pour nos Follistatin Protéines
Ishaq, Schang, Magre, Laverrière, Guillou, Coudouel, Wargnier, Cohen-Tannoudji, Counis: "Rat Gnrhr promoter directs species-specific gene expression in the pituitary and testes of transgenic mice." dans: Journal of molecular endocrinology, Vol. 50, Issue 3, pp. 411-26, (2013) (PubMed).
Li, Shimono, Norioka, Nakano, Okubo, Yagi, Hayashi, Sato, Fujisaki, Hattori, Sugiura, Kimata, Sekiguchi: "Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity." dans: The Journal of biological chemistry, Vol. 285, Issue 47, pp. 36645-55, (2010) (PubMed).
Umezu, Yamanouchi, Iida, Miura, Tomooka: "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 10, pp. 4601-6, (2010) (PubMed).
Rose, Mattis, Rindt, Lorson: "Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy." dans: Human molecular genetics, Vol. 18, Issue 6, pp. 997-1005, (2009) (PubMed).