This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
custom-made
FTH1
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
FTH1
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
FTH1
Origine: Souris
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
FTH1
Origine: Humain
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: "Impact of TET2 deficiency on iron metabolism in erythroblasts." dans: Experimental hematology, Vol. 49, pp. 56-67.e5, (2017) (PubMed).
Chou, Gatti, Fuller, Concannon, Wong, Chada, Davis, Salser: "Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro." dans: Molecular and cellular biology, Vol. 6, Issue 2, pp. 566-73, (1987) (PubMed).
Boyd, Vecoli, Belcher, Jain, Drysdale: "Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones." dans: The Journal of biological chemistry, Vol. 260, Issue 21, pp. 11755-61, (1985) (PubMed).
Costanzo, Santoro, Colantuoni, Bensi, Raugei, Romano, Cortese: "Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family." dans: The EMBO journal, Vol. 3, Issue 1, pp. 23-7, (1984) (PubMed).
Pseudonymes pour FTH1 Protéines
ferritin heavy chain 1 (FTH1) Protéines ferritin, heavy polypeptide 1 L homeolog (fth1.L) Protéines ferritin, heavy polypeptide 1 S homeolog (fth1.S) Protéines ferritin heavy polypeptide 1 (Fth1) Protéines ferritin heavy chain 1 (Fth1) Protéines ferritin, heavy polypeptide 1a (fth1a) Protéines ferritin (EAMY_RS19690) Protéines ferritin, heavy polypeptide 1 (fth1) Protéines tudor domain containing 9 (TDRD9) Protéines ferritin, heavy polypeptide 1 (FTH1) Protéines ferritin, heavy polypeptide 1 a (fth1a) Protéines apoferritin Protéines fb06g09 Protéines ferritin Protéines FHC Protéines fhc Protéines FTH Protéines fth Protéines Fth Protéines fth1 Protéines fth1b Protéines FTHL6 Protéines fthl6 Protéines ftn-2 Protéines HFt Protéines hm:zeh1145 Protéines MFH Protéines PIG15 Protéines pig15 Protéines PLIF Protéines plif Protéines wu:fb06g09 Protéines wu:fq18c10 Protéines zeh1145 Protéines