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GNAT3 Produits

(Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))

Catégories

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase\; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

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Catégories GNAT3 en vedette

GNAT3 Anticorps

High quality antibodies with extensive validation data.

GNAT3 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GNAT3 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (3)
N° du produit ABIN654441
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (3)
N° du produit ABIN7243340
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7154719
Quantité 100 μL
Fiche technique Fiche technique

GNAT3 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3135127
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3092787
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN2722098
Quantité 20 μg
Fiche technique Fiche technique

Dernières publications sur nos produits GNAT3

Jang, Kokrashvili, Theodorakis, Carlson, Kim, Zhou, Kim, Xu, Chan, Juhaszova, Bernier, Mosinger, Margolskee, Egan: "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 38, pp. 15069-74, (2007) (PubMed).

Ma, Sheng, Zhang, Zhang, He, Huang, Chen, Sultz, Adegboyega, Zhang, Xie: "Hedgehog signaling is activated in subsets of esophageal cancers." dans: International journal of cancer. Journal international du cancer, Vol. 118, Issue 1, pp. 139-48, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à GNAT3

G protein subunit alpha transducin 3 (GNAT3), guanine nucleotide binding protein, alpha transducing 3 (Gnat3), G protein subunit alpha transducin 3 (Gnat3), GDCA, Ggust, gnat-3, Gtn

Protein level used designations for GNAT3

  • guanine nucleotide-binding protein G(t) subunit alpha-3
  • gustducin
  • guanine nucleotide binding protein, alpha transducing 3
  • guanine nucleotide-binding protein G(t) subunit alpha-3-like
  • gustducin alpha-3 chain
  • alpha-gustducin
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