HLA-B Produits
(Major Histocompatibility Complex, Class I, B (HLA-B))
Catégories
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].
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Catégories HLA-B en vedette
HLA-B Anticorps
High quality antibodies with extensive validation data.
HLA-B Kits ELISA
Reliable ELISA kits for a wide range of species.
HLA-B Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
HLA-B recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (5)
- (6)
N° du produit
ABIN1944779
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
N° du produit
ABIN7440755
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS, IHC, ICC
Validations
- (7)
N° du produit
ABIN5542339
Quantité
0.1 mg
Fiche technique
Fiche technique
HLA-B recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957622
Quantité
96 tests
Fiche technique
Fiche technique
HLA-B recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123829
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN2752813
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7412851
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits HLA-B
: "A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E ..." dans: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 34895-903, (2012) (PubMed).: "Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells." dans: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38054-9, (2011) (PubMed).
: "Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells." dans: Journal of virology, Vol. 86, Issue 1, pp. 527-41, (2011) (PubMed).
: "Further molecular diversity in the HLA-B15 group." dans: Tissue antigens, Vol. 47, Issue 4, pp. 265-74, (1996) (PubMed).
: "HLA-B15: a widespread and diverse family of HLA-B alleles." dans: Tissue antigens, Vol. 43, Issue 4, pp. 209-18, (1994) (PubMed).
: "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens." dans: Tissue antigens, Vol. 38, Issue 4, pp. 186-90, (1992) (PubMed).
: "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 10, pp. 3411-5, (1992) (PubMed).
: "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci." dans: Nature, Vol. 357, Issue 6376, pp. 329-33, (1992) (PubMed).
Synonymes et noms alternatifs relatifs à HLA-B
major histocompatibility complex, class I, B (HLA-B), major histocompatibility complex, class I, B (BOLA-B), major histocompatibility complex, class I, B (MAMU-B18), major histocompatibility complex, class I, B (DKFZP469N1225), major histocompatibility complex nonclassical class Ib L homeolog (mhc1b.L), AS, HLAB, mhc1b, SPDA1Protein level used designations for HLA-B
- HLA class I histocompatibility antigen, B alpha chain
- MHC Class I HLA heavy chain
- MHC HLA-B cell surface glycoprotein
- MHC HLA-B transmembrane glycoprotein
- MHC class I antigen GN00104
- MHC class I antigen HLA-B heavy chain
- MHC class I antigen SHCHA
- leukocyte antigen class I-B
- lymphocyte antigen
- major histocompatibility complex, class I, B
- major histocompatibility complex nonclassical class Ib L homeolog
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