INSIG1 Produits
(Insulin Induced Gene 1 (INSIG1))
Catégories
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009].
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Catégories INSIG1 en vedette
INSIG1 Anticorps
High quality antibodies with extensive validation data.
INSIG1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7156348
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN652887
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC, IF, ICC
Validations
- (3)
N° du produit
ABIN6262599
Quantité
100 μL
Fiche technique
Fiche technique
INSIG1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6228955
Quantité
96 tests
Fiche technique
Fiche technique
INSIG1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3109916
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3124684
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7422967
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits INSIG1
: "LncRNA as ceRNAs may be involved in lactation process." dans: Oncotarget, Vol. 8, Issue 58, pp. 98014-98028, (2017) (PubMed).: "Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective." dans: Journal of cellular physiology, Vol. 228, Issue 7, pp. 1561-7, (2013) (PubMed).
: "Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system." dans: Acta physiologica (Oxford, England), Vol. 206, Issue 1, pp. 62-71, (2012) (PubMed).
: "Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin." dans: Biochimie, Vol. 93, Issue 7, pp. 1165-71, (2011) (PubMed).
: "Sex differences in hepatic regulation of cholesterol homeostasis." dans: The Journal of endocrinology, Vol. 198, Issue 3, pp. 635-43, (2008) (PubMed).
: "Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression." dans: Molecular pharmacology, Vol. 73, Issue 4, pp. 1282-9, (2008) (PubMed).
: "Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake." dans: Cell metabolism, Vol. 3, Issue 1, pp. 15-24, (2006) (PubMed).
: "Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins." dans: The Journal of clinical investigation, Vol. 115, Issue 9, pp. 2489-98, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à INSIG1
insulin induced gene 1 (INSIG1), insulin induced gene 1 (insig1), insulin induced gene 1 L homeolog (insig1.L), insulin induced gene 1 (Insig1), 1810013C12Rik, cl-6, CL-6, cl6, CL6, fb55a03, fi35b10, Insig-1, INSIG-1, wu:fb55a03, wu:fi35b10, zgc:55439Protein level used designations for INSIG1
- insulin induced gene 1
- INSIG-1
- insulin-induced gene 1 protein
- INSIG-1 membrane protein
- growth response protein (CL-6)
- immediate-early protein CL-6
- insulin-induced growth response protein CL-6
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