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Anacardic Acid

Name: Anacardic Acid
Brand: antibodies-online
SKU: ABIN7233231
Price: 126.92 EUR
Availability: InStock

Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

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N° du produit ABIN7233231

Fiche de données

Application

Inhibition (Inh)

Fonction

HAT Inhibitor

Attributs du produit

Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 μM) and PCAF (IC50 = 5.0 μM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 μM) and -9. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB. When used at 125 μM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells.

Pureté

>98 %

Chemical Name

2-Hydroxy-6-pentadecylbenzoic acid

Formula

C22H36O3

Solubility

Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (15 mg/ml)
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Radicicol
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Restrictions

For Research Use only
Format

Powder

Stock

-20 °C
Sujet

6-Pentadecylsalicylic acid, 6-PDSA,Cell adhesion,Epigenetics,Posttranslational modification,Cytokine,MAPK,Acetyltransferase,Protease,Immunology,Angiogenesis,Stem cells,Inflammation,Cancer,NFkappaB,Chromatin

Poids moléculaire

348.5

Numéro CAS

16611-84-0