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Embelin

Inh Cell-permeable 550-24-3 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

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N° du produit ABIN7233250

Fiche de données

Application

Inhibition (Inh)

Fonction

XIAP inhibitor, Apoptosis inducer

Attributs du produit

Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells. Possesses anti-inflammatory and analgesic activity in vivo. Cell-permeable.

Pureté

>98 %

Chemical Name

2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

Formula

C17H26O4

Perméabilité

Cell-permeable

Solubility

Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming)
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Radicicol
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Restrictions

For Research Use only
Format

Powder

Stock

-20 °C
Sujet

Epigenetics,Posttranslational modification,Acetyltransferase,Cell death,Inflammation,Cancer,Chromatin,Apoptosis inducer

Poids moléculaire

294.39

Numéro CAS

550-24-3