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Nicotinamide

Inh 98-92-0 Pyridine-3-carboxylic acid amide
N° du produit ABIN7233271
  • Application
    Inhibition (Inh)
    Fonction
    SIRT1 inhibitor, essential nutrient
    Attributs du produit
    Essential nutrient (amide form of Vitamin B3) that is incorporated into cofactors NADH/NAD+, important for ATP production and other key metabolic functions. Transiently inhibits SIRT1/SIRT3 through feedback inhibition (IC50 ~ 50 μM), but is quickly converted to NAD+ in cells. Also inhibits certain kinases (e.g. ROCK and CK1), making it a regulator of hPSC pluripotency, survival, and differentiation. Inhibits differentiation and enhances functionality of hematopoietic stem/progenitor cells (HSPCs).
    Pureté
    >99 %
    Chemical Name
    Pyridine-3-carboxylic acid amide
    Formula
    C6H6N2O
    Solubility
    Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    RT
  • Sujet
    Nicotinic acid amide, Niacinamide, Vitamin B3, NAM,Epigenetics,DNA damage,Protein deacetylase,Kinase,Stem cells,Cancer,NAD, NADP pathways,Posttranslational modification
    Poids moléculaire
    122.1
    Numéro CAS
    98-92-0
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