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Santacruzamate A

Name: Santacruzamate A
Brand: antibodies-online
SKU: ABIN7233286
Price: 133.38 EUR
Availability: InStock

Inh 1477949-42-0 N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

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N° du produit ABIN7233286

Fiche de données

Application

Inhibition (Inh)

Fonction

Ultrapotent HDAC2 inhibitor

Attributs du produit

A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance. Ameliorates Alzheimer's disease-like pathology in mouse models.

Pureté

>98 %

Chemical Name

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

Formula

C15H22N2O3

Solubility

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
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Radicicol
Inh 12772-57-5

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Restrictions

For Research Use only
Format

Powder

Précaution d'utilisation

GHS – Classification
Not a hazardous substance

Stock

-20 °C
Sujet

Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Cellular stress,Cancer,Neurodegeneration,Apoptosis inducer,Chromatin

Poids moléculaire

278.35

Numéro CAS

1477949-42-0