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GW-2580

870483-87-7 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine.

Serum-deprived cells were stimulated with 10 ng/mL Recombinant human BDNF protein (ABIN7482102) following pre-incubation with control, 1 μM, 10 μM and 100 μM (ABIN7885815). (GW-2580)

BCA

Dose-response curve of (ABIN7885815) inhibition of 50 ng/mL Recombinant human beta-NGF protein (ABIN7482098) mediated survival of serum-deprived PC12 cells. (GW-2580)

BCA

3 images

N° du produit ABIN7885815

320,77 €

Plus frais de livraison 40,00 € et TVA

10 mg

Destination: France

Envoi sous 8 à 9 jours ouvrables

Aperçu rapide pour GW-2580 (ABIN7885815)

Chemical Name

5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine.

Hôte

Synthetic

Fonction

An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases

Specificité

Toxin target: CSF-1R receptor, Trk receptor

Attributs du produit

GW-2580 is a potent and selective inhibitor of cFMS/CSF-1 receptor kinase, shown to completely and selectively inhibit human cFMS kinase activity at 60 nM, and fully suppress CSF-1 induced cell growth at 1 μM, in vitro. Orally bioavailable and active in vivo1. GW 2580 also binds to TrkB, TrkC and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively,2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 μM3.

Pureté

>99 %

Formula

C20H22N4O3.

Solubility

Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Thapsigargin
67526-95-8 (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6 ,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[ [(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutox y)azuleno[4,5-b]furan-7-yl octanoate.

K252a
97161-97-2 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-.

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

(±)-Bay K8644
71145-03-4 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester.

Capsaicin
404-86-4 (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide.

Chelerythrine chloride
3895-92-9 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride.

K252b
99570-78-2 (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid.

GS967
1262618-39-2 (6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine)

Restrictions

For Research Use only
Format

Powder

Conseil sur la manipulation

Centrifuge all product preparations before use (10000 x g 5 min).

Stock

-20 °C

Stockage commentaire

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Poids moléculaire

366.41

Numéro CAS

870483-87-7