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KCC2 Produits

(Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))

Catégories

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].

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Catégories KCC2 en vedette

KCC2 Anticorps

High quality antibodies with extensive validation data.

KCC2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

KCC2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Application WB, IHC, IP, IF, ICC
Validations
  • (4)
N° du produit ABIN1027708
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (3)
N° du produit ABIN7075650
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
N° du produit ABIN652057
Quantité 400 μL
Fiche technique Fiche technique

KCC2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6210805
Quantité 96 tests
Fiche technique Fiche technique

KCC2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3087605
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3087606
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3127245
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits KCC2

Dumon, Diabira, Chudotvorova, Bader, Sahin, Zhang, Porcher, Wayman, Medina, Gaiarsa: "The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice." dans: eLife, Vol. 7, (2019) (PubMed).

Kwon, Neupane, Shin, Gwon, Yin, Shin, Shin, Hong, Park, Yi, Kim, Kang: "Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats." dans: Experimental neurobiology, Vol. 28, Issue 4, pp. 529-536, (2019) (PubMed).

Huang, Grau: "Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain." dans: Experimental neurology, Vol. 306, pp. 105-116, (2019) (PubMed).

Mahadevan, Khademullah, Dargaei, Chevrier, Uvarov, Kwan, Bagshaw, Pawson, Emili, De Koninck, Anggono, Airaksinen, Woodin: "Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition." dans: eLife, Vol. 6, (2018) (PubMed).

Stödberg, McTague, Ruiz, Hirata, Zhen, Long, Farabella, Meyer, Kawahara, Vassallo, Stivaros, Bjursell, Stranneheim, Tigerschiöld, Persson, Bangash, Das, Hughes, Lesko, Lundeberg, Scott, Poduri et al.: "Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. ..." dans: Nature communications, Vol. 6, pp. 8038, (2015) (PubMed).

Mahadevan, Dargaei, Ivakine, Hartmann, Ng, Chevrier, Ormond, Nothwang, McInnes, Woodin: "Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures." dans: Frontiers in cellular neuroscience, Vol. 9, pp. 368, (2015) (PubMed).

Toda, Ishida, Kiyama, Yamashita, Lee: "Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity." dans: PLoS ONE, Vol. 9, Issue 12, pp. e114328, (2015) (PubMed).

He, Nomura, Xu, Contractor: "The developmental switch in GABA polarity is delayed in fragile X mice." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 2, pp. 446-50, (2014) (PubMed).

Markkanen, Karhunen, Llano, Ludwig, Rivera, Uvarov, Airaksinen: "Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS." dans: The Journal of comparative neurology, Vol. 522, Issue 8, pp. 1897-914, (2014) (PubMed).

Law, Paquet, Kania: "Emergence of motor circuit activity." dans: PLoS ONE, Vol. 9, Issue 4, pp. e93836, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à KCC2

solute carrier family 12 member 5 (SLC12A5), solute carrier family 12 member 5 (Slc12a5), solute carrier family 12, member 5 (Slc12a5), Kcc2, KCC2, mKIAA1176

Protein level used designations for KCC2

  • solute carrier family 12 (potassium/chloride transporter), member 5
  • K-Cl cotransporter 2
  • electroneutral potassium-chloride cotransporter 2
  • furosemide-sensitive K-Cl cotransporter
  • neuronal K-Cl cotransporter
  • neuronal-specific K-Cl cotransporter
  • rKCC2
  • solute carrier family 12 member 5
  • solute carrier family 12, member 5
  • erythroid K-Cl cotransporter 2
  • hKCC2
  • mKCC2
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