SensoLyte® 490 MMP-12 Assay Kit

N° du produit ABIN1882513

Aperçu rapide pour SensoLyte® 490 MMP-12 Assay Kit (ABIN1882513)

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Méthode de détection: Fluorometric

Application: Fluorescence Resonance Energy Transfer Microscopy (FRET)

Détail du produit

Marque: SensoLyte®

Attributs du produit: The SensoLyte® 490 MMP-12 Assay Kit is a complete assay system designed to continuously analyze MMP-12 activity or to screen for MMP-12 inhibitors by using a fluorogenic MMP-12 substrate.

Information d'application

Commentaires:

FRET-based Assay Kit

Restrictions: For Research Use only

Stockage

Conseil sur la manipulation: Protect Components A and B from light.

Stock: -20 °C

Stockage commentaire: Store all components at -20 °C. Components D and E can be stored at 4 °C for convenience.

Référence

Song, Xie, Liu, Zhao, Yu, Ban, Ye, Wen, Wan, Li, Ma, Meng: "Expression of matrix metalloproteinase-12 in aortic dissection." dans: BMC cardiovascular disorders, Vol. 13, pp. 34, (2013) (PubMed).

Chan, Chan, Yeung, Man, Ip, Mak: "Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity." dans: Free radical research, Vol. 46, Issue 9, pp. 1123-9, (2012) (PubMed).

Bogaert, Naessens, De Koker, Hennuy, Hacha, Smet, Cataldo, Di Valentin, Piette, Tournoy, Grooten: "Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 300, Issue 5, pp. L679-90, (2011) (PubMed).

Qu, Du, Wang, Yan: "Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition." dans: Cancer research, Vol. 69, Issue 18, pp. 7252-61, (2009) (PubMed).

Takiyama, Kinoshita, Kinoshita-Kikuta, Fujioka, Kubo, Koike: "A Phos-tag-based fluorescence resonance energy transfer system for the analysis of the dephosphorylation of phosphopeptides." dans: Analytical biochemistry, Vol. 388, Issue 2, pp. 235-41, (2009) (PubMed).

Ma, Tittiger, Knutsen, Kovacs, Schaller, Mecham, Ponder: "Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice." dans: Molecular genetics and metabolism, Vol. 94, Issue 3, pp. 298-304, (2008) (PubMed).

Summer, Little, Ouchi, Takemura, Aprahamian, Dwyer, Fitzsimmons, Suki, Parameswaran, Fine, Walsh: "Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 6, pp. L1035-42, (2008) (PubMed).

Demedts, Morel-Montero, Lebecque, Pacheco, Cataldo, Joos, Pauwels, Brusselle: "Elevated MMP-12 protein levels in induced sputum from patients with COPD." dans: Thorax, Vol. 61, Issue 3, pp. 196-201, (2006) (PubMed).

Détail du antigène

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Autre désignation: MMP-12

Sujet: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is implicated in the pathology of many diseases such as emphysema, aortic lesions and cancer. It has recently been shown to play a role in the pathogenesis of rheumatoid arthritis.