IL-10 Kit ELISA

N° du produit ABIN2042518

Kit ELISA Rat IL-10, test Colorimetric pour la quantification de Rat IL-10.

Aperçu rapide pour IL-10 Kit ELISA (ABIN2042518)

Antigène: IL-10 (IL10) (Interleukin 10 (IL10))

Reactivité: Rat

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 31.2-2000 pg/mL

Application: ELISA

Détail du produit IL-10 Kit ELISA

Seuil minimal de détection: 31.2 pg/mL

Réactivité croisée (Details): No detectable crossreactivity with other relevant proteins

Sensibilité: < 4 pg/mL

Ingrédients: A: Microtiter Strips, 1x96 wells
B: IL-10 Standard, 2x10 ng
C: Anti-rat IL-10 (Biotin), 130 µL

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C/-20 °C

Détail du antigène

Antigène: IL-10 (IL10) (Interleukin 10 (IL10))

Autre désignation: IL-10

Sujet: Interleukin-10, also called cytokine synthesis inhibitory factor, is implicated in tumorigenesis, and it has been shown that polymorphisms in its gene promoter correlate with differential amounts of production (1). IL-10 is an important cytokine with anti-inflammatory, anti-immune, and antifibrotic functions (2). It is also an important regulatory cytokine whose involvement extends into diverse areas of the human immune system (3). IL-10 is a recently described natural endogenous immunosuppressive cytokine that has been identified in human, murine, and other organisms. IL-10 significantly affects chemokine biology, because human IL-10 inhibits chemokine production and is a specific chemotactic factor for CD8+ T cells. It suppresses the ability of CD4+ T cells, but not CD8+ T cells, to migrate in response to IL-8 (4). Interleukin-10 gene polymorphisms and interleukin-10 production capability may contribute to the development of skin squamous cell carcinomas after renal transplantation (1). The interleukin-10 locus contributes to the heritability of psoriasis susceptibility (5). With regard to sudden infant death, IL-10 is of special interest. This is an immunoregulatory cytokine that plays an important role in the development of infectious disease (6). The mIL-10 gene is mapped to mouse chromosome 1 and the hIL-10 gene is also mapped to human chromosome 1 (7).

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints