Thrombomodulin Kit ELISA

N° du produit ABIN5510595

Kit ELISA Singe Thrombomodulin, test Colorimetric pour la quantification de Singe Thrombomodulin.

Aperçu rapide pour Thrombomodulin Kit ELISA (ABIN5510595)

Antigène: Thrombomodulin (THBD)

Épitope: AA 19-515

Reactivité: Singe

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Détail du produit Thrombomodulin Kit ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of monkey primate Thrombomodulin

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: A19-S515

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Sequence similarities: Contains 1 C-type lectin domain.

Tissue Specificity: Endothelial cells are unique in synthesizing thrombomodulin.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: Thrombomodulin (THBD)

Autre désignation: THBD

Sujet:

Protein Function: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Background: Thrombomodulin(TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on monkey primate mesothelial cell, monocyte and a dendritic cell subset. In humans, thrombomodulin is encoded by the THBD gene. The protein has a molecular mass of 74 kDa, and consists of a single chain with 5 distinct domains. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor(TAFI,aka carboxypeptidase B2) into its active form. Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene(THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome(aHUS).

Synonyms: Thrombomodulin,TM,Fetomodulin,CD141,THBD,THRM,

Full Gene Name: Thrombomodulin

Cellular Localisation: Membrane, Single-pass type I membrane protein.

UniProt: P07204