MUC16 Kit ELISA

N° du produit ABIN5510649

Kit ELISA Humain MUC16, test Colorimetric pour la quantification de Humain MUC16 et a été mentionné dans 1 publication.

Aperçu rapide pour MUC16 Kit ELISA (ABIN5510649)

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Épitope: AA 21005-21992

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Détail du produit MUC16 Kit ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CA125/MUC16

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: CHO
Immunogen sequence: M21005-Q21992

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Références pour MUC16 Kit ELISA (ABIN5510649)

Li, Zhang, Wang, Li, Cao, Tan, Ma, Gao: "TGFβ1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells." dans: Oncotarget, Vol. 8, Issue 56, pp. 96035-96047, (2017) (PubMed).

Détail du antigène

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Autre désignation: MUC16

Sujet:

Protein Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. .

Background: CA-125, also known as mucin 16 or MUC16, is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. It is a component of the ocular surface, the respiratory tract and the female reproductive tract epithelia. Since MUC16 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells. Also, the cytoplasmic tail of MUC16 has been shown to interact with cytoskeleton by binding members of the ERM protein family. The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers.

Synonyms: Mucin-16 ,MUC-16,Ovarian cancer-related tumor marker CA125 ,CA-125 ,Ovarian carcinoma antigen CA125 ,MUC16 ,CA125 ,

Full Gene Name: Mucin-16

Cellular Localisation: Cell membrane, Single-pass type I membrane protein. Secreted, extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

UniProt: Q8WXI7