EDIL3 Kit ELISA

N° du produit ABIN5510665

Ce kit ELISA Colorimetric est conçu pour la mesure quantitative de Humain EDIL3.

Aperçu rapide pour EDIL3 Kit ELISA (ABIN5510665)

Antigène: EDIL3 (DEL1) (EGF like repeats and discoidin domains 3 (DEL1))

Épitope: AA 24-480

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Détail du produit EDIL3 Kit ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human EDIL3

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: D24-E480

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: EDIL3 (DEL1) (EGF like repeats and discoidin domains 3 (DEL1))

Autre désignation: EDIL3

Sujet:

Protein Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

Background: EDIL3, also known as DEL1, is a glycoprotein that is secreted by endothelial cells and can associate with the endothelial cell surface and the extracellular matrix. It is regulated by hypoxia or vascular injury and has been implicated in vascular remodeling during angiogenesis. The EDIL3 gene is mapped to 5q14. Human endothelial cells bind to Del1 together with the alpha-V (ITGAV)/beta-3 (ITGB3) integrin receptor. It is confirmed that adhesion of endothelial cells to Del1 is integrin mediated and that Del1 binds ITGAV/ITGB3. Functional analysis showed that both Del1 and vitronectin (VTN) stimulate endothelial cell migration. Immunoprecipitation and immunoblot analyses revealed that adhesion of endothelial cells to Del1 induces tyrosine phosphorylation of PTK2.

Synonyms: EGF-like repeat and discoidin I-like domain-containing protein 3,Developmentally-regulated endothelial cell locus 1 protein,Integrin-binding protein DEL1,EDIL3,DEL1,

Full Gene Name: EGF-like repeat and discoidin I-like domain-containing protein 3

Cellular Localisation: Secreted.

UniProt: O43854