GDF5 Kit ELISA

N° du produit ABIN5510677

Ce kit ELISA Colorimetric est conçu pour la mesure quantitative de Souris GDF5.

Aperçu rapide pour GDF5 Kit ELISA (ABIN5510677)

Antigène: GDF5 (Growth Differentiation Factor 5 (GDF5))

Épitope: AA 376-495

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Détail du produit GDF5 Kit ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse GDF5

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: E.coli
Immunogen sequence: A376-R495

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: GDF5 (Growth Differentiation Factor 5 (GDF5))

Autre désignation: Gdf5

Sujet:

Protein Function: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). .

Background: Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene. GDF5 is a protein belonging to the transforming growth factor beta superfamily that is expressed in the developing central nervous system, and has a role in skeletal and joint development. It also increases the survival of neurones that respond to the neurotransmitter dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.

Synonyms: Growth/differentiation factor 5,GDF-5,Bone morphogenetic protein 14,BMP-14,Gdf5,Bmp14, Bp, Gdf-5,

Full Gene Name: Growth/differentiation factor 5

Cellular Localisation: Secreted . Cell membrane.

UniProt: P43027