FOLR2 Kit ELISA

N° du produit ABIN5510703

Détail du produit FOLR2 Kit ELISA

Antigène: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Épitope: AA 17-230

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human FOLR2

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: T17-N230

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Autre désignation: FOLR2 (FOLR2 Produits)

Synonymes: FOLR2 Kit ELISA, BETA-HFR Kit ELISA, FBP Kit ELISA, FBP/PL-1 Kit ELISA, FR-BETA Kit ELISA, FR-P3 Kit ELISA, FBP2 Kit ELISA, Folbp-2 Kit ELISA, Folbp2 Kit ELISA, folate receptor 1 Kit ELISA, folate receptor beta Kit ELISA, folate receptor 2 (fetal) Kit ELISA, FOLR1 Kit ELISA, FOLR2 Kit ELISA, Folr2 Kit ELISA

Sujet:

Protein Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH . Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. .

Background: Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68 % and 79 % sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.

Synonyms: Folate receptor beta,FR-beta,Folate receptor 2,Folate receptor, fetal/placental,Placental folate-binding protein,FBP,FOLR2,

Full Gene Name: Folate receptor beta

Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor. Secreted.

UniProt: P14207

Pathways: Dicarboxylic Acid Transport