SIGLEC5 Kit ELISA

N° du produit ABIN5510738

Ce kit ELISA Humain SIGLEC5 est un kit ELISA Colorimetric conçu pour quantifier Humain SIGLEC5.

Aperçu rapide pour SIGLEC5 Kit ELISA (ABIN5510738)

Antigène: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Épitope: AA 17-441

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Détail du produit SIGLEC5 Kit ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Siglec5

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: E17-L441

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Autre désignation: SIGLEC5

Sujet:

Protein Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Background: Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Synonyms: Sialic acid-binding Ig-like lectin 5,Siglec-5,CD33 antigen-like 2,Obesity-binding protein 2,OB-BP2,OB-binding protein 2,CD170,SIGLEC5,CD33L2, OBBP2,

Full Gene Name: Sialic acid-binding Ig-like lectin 5

Cellular Localisation: Membrane, Single-pass type I membrane protein.

UniProt: O15389