IL1F9 Kit ELISA

N° du produit ABIN5564184

Détail du produit IL1F9 Kit ELISA

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 3.9-250 pg/mL

Seuil minimal de détection: 3.9 pg/mL

Application: ELISA

Type d'échantillon: Cell Culture Supernatant, Serum

Analytical Method: Quantitative

Specificité: Detects natural and recombinant human IL-36gamma.

Réactivité croisée: Humain

Sensibilité: 3 pg/mL

Attributs du produit: IL-36gamma (human) ELISA Kit

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: +4°C
12 months after the day of manufacturing. See expiry date on ELISA Kit box.

Détail du antigène

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Autre désignation: IL-36gamma (IL1F9 Produits)

Synonymes: IL-1F9 Kit ELISA, IL-1H1 Kit ELISA, IL-1RP2 Kit ELISA, IL1E Kit ELISA, IL1F9 Kit ELISA, IL1H1 Kit ELISA, IL1RP2 Kit ELISA, Il36g Kit ELISA, Il1f9 Kit ELISA, RGD1563019 Kit ELISA, IL36G Kit ELISA, interleukin 36 gamma Kit ELISA, interleukin 1 family, member 9 Kit ELISA, interleukin 36, gamma Kit ELISA, interleukin-36 gamma Kit ELISA, IL36G Kit ELISA, Il1f9 Kit ELISA, Il36g Kit ELISA, LOC100065031 Kit ELISA

Sujet: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) are members of the IL-1 cytokine family that bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines occurs mainly in the lung and skin and can be derived from diverse epithelial cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of pro-inflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. Induction of IL-36gamma in macrophages upon M. tuberculosis infection and its role in the release of antimicrobial peptides has been proposed. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines and plays an important role in asthmatic pulmonary inflammation. IL-36gamma might be a potential biomarker of Inflammatory Bowel Disease and is highly expressed in inflamed skin from psoriasis patients and in Allergic Contact Dermatitis. IL-36gamma serum levels are enhanced and correlate to psoriasis severity and response to treatment with anti-TNF.