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DC-SIGN/CD209 Kit ELISA

CD209 Reactivité: Humain AA 59-404 Colorimetric Sandwich ELISA 93.7 pg/mL - 6000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
N° du produit ABIN5692223
  • Antigène Voir toutes DC-SIGN/CD209 (CD209) Kits ELISA
    DC-SIGN/CD209 (CD209) (CD209)
    Épitope
    AA 59-404
    Reactivité
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Gamme de detection
    93.7 pg/mL - 6000 pg/mL
    Seuil minimal de détection
    93.7 pg/mL
    Application
    ELISA
    Fonction
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CD209. 96wells/kit, with removable strips.
    Marque
    PicoKine™
    Type d'échantillon
    Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
    Analytical Method
    Quantitative
    Specificité
    Expression system for standard: NSO, Immunogen sequence: Q59-A404
    Sensibilité
    < 10 pg/mL
    Ingrédients
    96-well plate precoated with antibody
    lyophilized recombinant standard
    biotinylated antibody (dilution 1:100)
    Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
    Sample diluent buffer
    Antibody diluent buffer
    ABC diluent buffer
    TMB color developing agent
    TMB stop solution
    Adhesive cover
  • Durée du test
    15 min
    Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Date de péremption
    12 months
  • Antigène Voir toutes DC-SIGN/CD209 (CD209) Kits ELISA
    DC-SIGN/CD209 (CD209) (CD209)
    Autre désignation
    CD209 (CD209 Produits)
    Synonymes
    CDSIGN Kit ELISA, CLEC4L Kit ELISA, DC-SIGN Kit ELISA, DC-SIGN1 Kit ELISA, cd209 Kit ELISA, CLEC4M Kit ELISA, si:ch211-224h1.3 Kit ELISA, CD209 Kit ELISA, CIRE Kit ELISA, Dcsign Kit ELISA, SIGN-R1 Kit ELISA, SIGNR5 Kit ELISA, Cd209 Kit ELISA, CD209 molecule Kit ELISA, CD209a antigen Kit ELISA, CD209 antigen-like protein D Kit ELISA, CD209c molecule Kit ELISA, CD209 antigen Kit ELISA, CD209 Kit ELISA, cd209 Kit ELISA, Cd209a Kit ELISA, LOC100529184 Kit ELISA, Cd209c Kit ELISA, LOC100460708 Kit ELISA, LOC105484282 Kit ELISA
    Sujet

    Synonyms: CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN, DC-SIGN1, CD209, CD209, CLEC4L

    Tissue Specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

    Background: DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene. DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

    Cellular Localisation: Isoform 1: Cell membrane, Single-pass type II membrane protein.
    UniProt
    Q9NNX6
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