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PRTN3 Kit ELISA

PRTN3 Colorimetric Competition ELISA
N° du produit ABIN996889
  • Antigène Voir toutes PRTN3 Kits ELISA
    PRTN3 (Proteinase 3 (PRTN3))
    Méthode de détection
    Colorimetric
    Type de méthode
    Competition ELISA
    Application
    ELISA
    Fonction
    Proteinase-3 (PR-3) Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the detection and semiquantitative determination of antibodies to PR-3 in human sera. The assay is to be used to detect antibodies in a single serum specimen. The results of the assay are to be used as an aid in the diagnosis of Wegener’s granulomatosis
    Analytical Method
    Semi-Quantitative
    Specificité
    95.6%
    Sensibilité
    98.2%
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  • Volume d'échantillon
    10 μL
    Durée du test
    1 - 2 h
    Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C
    Date de péremption
    12 months
  • Antigène Voir toutes PRTN3 Kits ELISA
    PRTN3 (Proteinase 3 (PRTN3))
    Autre désignation
    PR3 (c-ANCA) (PRTN3 Produits)
    Synonymes
    ela2 Kit ELISA, MGC132250 Kit ELISA, ACPA Kit ELISA, AGP7 Kit ELISA, C-ANCA Kit ELISA, CANCA Kit ELISA, MBN Kit ELISA, MBT Kit ELISA, NP-4 Kit ELISA, NP4 Kit ELISA, P29 Kit ELISA, PR-3 Kit ELISA, PR3 Kit ELISA, mPR3 Kit ELISA, proteinase 3 L homeolog Kit ELISA, proteinase 3 Kit ELISA, prtn3.L Kit ELISA, PRTN3 Kit ELISA, Prtn3 Kit ELISA
    Sujet
    Proteinase-3 is a lysosomal enzyme that can be found in human neutrophils. There are two subsets of autoantibodies to human neutrophils: c- ANCA and p-ANCA. The first subtype, c-ANCA, shows cytoplasmic staining by IFA and is diagnostic for Wegener's granulomatosis. The major antigen responsible for the c-ANCA staining is Proteinase-3. The second subtype, p-ANCA, shows perinuclear staining by IFA. The major antigen responsible for the p-ANCA response has been shown to be myeloperoxidase. The ANCA staining patterns are obtained using ethanol-fixed human neutrophils. Anti- PR-3 autoantibodies have been associated with Wegener's granulomatosis but less often with microscopic polyangiitis. Other antigen specificity's (CAP 57) can be responsible for the c-ANCA pattern. These antigens are generally not diagnostic for PR-3 associated vaculitus diseases.
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