ENO2/NSE Kit ELISA

N° du produit ABIN996903

Le kit ELISA ENO2/NSE (ABIN996903) est un kit ELISA Colorimetric conçu pour quantifier ENO2/NSE.

Aperçu rapide pour ENO2/NSE Kit ELISA (ABIN996903)

Antigène: ENO2/NSE (ENO2) (Enolase 2 (Gamma, Neuronal) (ENO2))

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 0-200 ng/mL

Application: ELISA

Type d'échantillon: Serum

Détail du produit ENO2/NSE Kit ELISA

Seuil minimal de détection: 0 ng/mL

Fonction: The Neuron-Specific Enolase (NSE) enzyme linked immunosorbent assay (ELISA) provides quantitative measurement of human NSE in serum to aid in the clinical evaluation of patients suspected of having small cell lung cancer, and other related diseases.

Analytical Method: Quantitative

Specificité: 98.7 %

Sensibilité: 15 ng/mL

Information d'application

Volume d'échantillon: 15 μL

Durée du test: 1 - 2 h

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Date de péremption: 12-14 months

Détail du antigène

Antigène: ENO2/NSE (ENO2) (Enolase 2 (Gamma, Neuronal) (ENO2))

Autre désignation: NSE

Sujet: The glycolytic enzyme enolase (2-phosph-D-glycerate hydrolyase) exists as several dimeric isoenzymes ( alphaalpha , alphabeta alphagamma and gammagamma ) composed of three distinct subunits, alpha , beta , and gamma . Three isoenzymes are found in human brain: alphaalpha , alphagamma and gammagamma . The alphagamma and gammagamma -enolase isoenzymes are also known as neuron-specific enolase (NSE) as these isoenzymes initially were detected in neurons and neuronendocrine cells. The NSE levels are low in health and benign subjects. Elevated levels are commonly found in patients with malignant tumors with neuronendocrine differentiation, especially small cell lung cancer and neuroblastoma. Lung cancer is one of the most spread cancer forms with incidences about 50~100 per 100,000 population.
Approximately 20% of the lung cancer is small cell lung cancer. Patients with small cell lung cancer show various proportions of alphagamma and gammagamma isoenzyme. The determination of NSE should detect and gamma isoforms with the same sensitivity. The antibodies for this particular assay are specific for the gamma -subunit without cross reactivity with alpha or beta subunits. NSE Kits are reported to be useful diagnostic marker for lung cancer, neuroblastoma, and melanoma, seminoma (S) and in injury of central nervous system. In addition to the above, NSE can be a valuable tool in following-up the effect of chemotherapy of small cell lung cancer, in prognostic evaluation of patients with small cell lung cancer, and in differential diagnosis between cell lung cancer and non-small cell lung cancer.