LIG4 Protéines
(Ligase IV, DNA, ATP-Dependent (LIG4))
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
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custom-made
LIG4
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
LIG4
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
LIG4
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
Greater than 90 % as determined by SDS-PAGE.
ELISA, WB
LIG4
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
ELISA, WB, SDS
custom-made
LIG4
Origine: Souris
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
LIG4
Origine: Humain
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Pseudonymes pour LIG4 Protéines
ligase IV, DNA, ATP-dependent (lig4) ProtéinesDNA ligase 4 (LIG4) Protéines
DNA ligase 4 (LOC100212302) Protéines
DNA ligase 4 (CpipJ_CPIJ005161) Protéines
DNA ligase 4 (PTRG_09982) Protéines
DNA ligase 4 (MCYG_05151) Protéines
DNA ligase 4 (LOC657210) Protéines
ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4) Protéines
DNA ligase IV (ATLIG4) Protéines
ligase IV, DNA, ATP-dependent L homeolog (lig4.L) Protéines
ligase IV, DNA, ATP-dependent (Lig4) Protéines
DNA ligase 4 (Lig4) Protéines
5830471N16Rik Protéines
DNA LIGASE IV Protéines
DNL4 Protéines
lig4 Protéines
LIG4 Protéines
lig4-A Protéines
tiny Protéines
zgc:165595 Protéines
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