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LIG4 Protéines

(Ligase IV, DNA, ATP-Dependent (LIG4))

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

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LIG4 Protein (AA 1-911) (His tag)

custom-made LIG4 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Lig4 Protein, UniprotID Q8BTF7

3 images

N° du produit ABIN7564421

Détails

LIG4 Protein (AA 1-911) (His tag)

custom-made LIG4 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant LIG4 Protein, UniprotID P49917

3 images

N° du produit ABIN7553715

Détails

LIG4 Protein (AA 724-911) (His-IF2DI Tag)

LIG4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB

N° du produit ABIN7664511

Détails

LIG4 Protein (His tag)

LIG4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant ELISA, WB, SDS

N° du produit ABIN7577952

Détails

LIG4 Protein (AA 1-911) (Strep Tag)

custom-made LIG4 Origine: Souris Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

N° du produit ABIN3136262

Détails

LIG4 Protein (AA 1-911) (Strep Tag)

custom-made LIG4 Origine: Humain Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

N° du produit ABIN3092165