The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010].
LDLR
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos Low Density Lipoprotein Receptor Protéines
Basak, Verghese, Yoon, Kim, Holtzman: "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of A? uptake and degradation by astrocytes." dans: The Journal of biological chemistry, Vol. 287, Issue 17, pp. 13959-71, (2012) (PubMed).
Prunotto, Carnevali, Candiano, Murtas, Bruschi, Corradini, Trivelli, Magnasco, Petretto, Santucci, Mattei, Gatti, Scolari, Kador, Allegri, Ghiggeri: "Autoimmunity in membranous nephropathy targets aldose reductase and SOD2." dans: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 3, pp. 507-19, (2010) (PubMed).
Pseudonymes pour Low Density Lipoprotein Receptor Protéines
low density lipoprotein receptor (LDLR) Protéines low density lipoprotein receptor (Ldlr) Protéines low density lipoprotein receptor a (ldlra) Protéines low density lipoprotein receptor S homeolog (ldlr.S) Protéines low density lipoprotein receptor L homeolog (ldlr.L) Protéines FH Protéines FHC Protéines fhc Protéines Hlb301 Protéines LDLA Protéines LDLCQ2 Protéines ldlcq2 Protéines ldlr Protéines ldlr-a Protéines ldlr-b Protéines ldlr2-a Protéines LDLRA Protéines LDL receptor-2 Protéines LDL receptor 1 Protéines