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Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin
The present study systematically evaluated the genetic effect of the estrogen metabolic pathway on alzheimer's based on 78 polymorphisms distributed across four genes. In the southern Chinese population, strong evidence of associations with AD were detected for polymorphisms in ESR2 and CYP11A1.
deregulation of miR-320a/RUNX2/CYP11A1 (CYP19A1) cascade plays an important role in the development of estrogen deficiency in human cumulus granulosa cells
The steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), cytochrome P450 17 alpha-hydroxylase (P450c17) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) showed immunoreactivity in 9/20 (45.0 %), 15/20 (75.0 %) and 13/20 (65.0 %), respectively, of ovarian-type stroma from pancreatic mucinous cystic neoplasm cases.
The findings of this study provided further support for the hypothesis that a susceptibility gene for autism spectrum disorder exists within or near the CYP11A1 gene in the Han Chinese population.
These findings contribute in clarifying the relationship between hormones regulating the early phase of steroidogenesis confirming that AMH is playing a suppressive role on CYP19A1 expression stimulated by gonadotropin in hGCs. Furthermore, a similar inhibitory effect for AMH was observed on P450scc gene expression when activated by gonadotropin treatment.
An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the predisposition to childhood asthma.
The study characterizes the intermediates in the second and third steps of the enzymatic process by which P450scc converts cholesterol to pregnenolone.
In prostate cancer, increased DNA methylation of SRD5A2 and CYP11A1 related to androgen biosynthesis functions may play a role in biochemical recurrence after patients' prostatectomy
polymorphisms of CYP11A1 are related to breast cancer susceptibility in Han Chinese women of South China.
Data indicate a role of cytochrome P450 11A1 (CYP11A1 in sterol metabolism.
CYP11A1 (tttta)(n) repeat polymorphism appeared to be a potential molecular marker for PCOS risk in our population. Gene-gene and gene-environmental interactions with respect to obesity may play a role in the early onset of this multifactorial condition.
There may be an association between CYP11A1 promoter pentanucleotide repeat polymorphism and polycystic ovary syndrome. (Meta-analysis)
This meta-analysis suggests that CYP11A1 microsatellite [TTTA]n repeat polymorphisms may contribute to increasing susceptibility to polycystic ovary syndrome among Caucasian populations.
the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower.
The results of this study demonistrated that Cyp11a1 is a target of SF-1 in gonadotroph cells and promotes proliferation/survival of rat pituitary adenoma primary cells and cell lines.
abnormally high expression of CYP11A inhibits trophoblastic proliferation and increases apoptosis and therefore could be involved in the pathogenesis of preeclampsia
study describes 7 patients with P450scc deficiency whose presentations ranged from severe neonatal adrenal crisis with wholly inactivating loss-of-function mutations in CYP11A1 to children who presented with normal male genitalia at up to 4 years of age
deficiencies in the steroidogenic acute regulatory protein and the cholesterol side chain cleavage enzyme cause neonatal adrenal failure
Tissues expressing P450scc can metabolize 7-dehydrocholesterol to biologically active 7-dehydropregnenolone.
melatonin not only elevated progesterone (P) secretion, but also upregulated expressions of StAR and Cyp11a1 and also had an increased Ihh expression in endometrium.
reduction in expression mirrored reduction in adrenal corticosterone output
The results demonstrated that ZnT7 gene silencing downregulated the expression of StAR, P450scc and 3beta-HSD as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.
1,25D3 modulates CD8+ T cell phenotype via recruitment of the VDR transcription factor to the promoter region of Cyp11a1 leading to prevention of lung allergic responses.
Data from Cyp11a1 transgenic mice suggest that overexpression of Cyp11a1 results in reduced pregnancy rate, impaired implantation/placentation, decreased litter size, and stillbirth; overexpression of Cyp11a1 disrupts development of corpus luteum.
Cyp11a1 plays an important role in the development of peanut allergy, regulating peanut-induced allergic responses through effects on steroidogenesis, an essential pathway in T(H)2 differentiation.
Cyp11a1 controls the phenotypic conversion of CD8(+) T cells from IFN-gamma to IL-13 production, linking steroidogenesis in CD8(+) T cells, a nonclassical steroidogenic tissue, to a proallergic differentiation pathway
Sodium fluoride inhibited expression of StAR and P450scc in mouse Leydig tumor cells, which inhibited progesterone secretion.
LH/hCG tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 by 8Br-cAMP.
Cyp11a1 null embryos had adrenal medulla with abnormal mitochondria. Cells did not synthesized no epinephrine. Decreased diencephalon Hsd11b1, increased Crh, and increased pituitary Pomc expression, thus higher plasma ACTH
Data suggest that the 5' flanking region of CYP11A gene contains sequences between 2.5 and 5 kb that are necessary for expression of mouse CYP11A in Leydig cells but not in adrenal cells. [REVIEW]
Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP stimulation.
Prenatal exposure to ethanol increased expressions of StAR and P450scc in maternal adrenal and decreased them in fetal adrenal.
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc, P450(17alpha) and 17beta-HSD in mice.
Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element.
Cyp11a1 null mice display a lack of steroid production, abnormal gene expression, and aberrant reproductive organ development resemble various steroid deficiency syndromes.
Male CYP11A1 null mice are feminized and their adrenals and genitalia accumulate excessive amounts of lipid
Proximal SF-1 binding site plays important role in regulating tissue-specific expression of Cyp11a1 and stress response.
This study sought to elucidate overlooked modes of regulation of P450scc transcription in the rodent placenta and ovary.
SF-1 and AP-1 cooperate to activate CYP11A1 transcription in vitro and in vivo.
We constructed cDNA including genes of the bovine cholesterol hydroxylase/lyase (CHL) system proteins-cytochrome P450scc (CYP11A1), adrenodoxin (Adx) and adrenodoxin reductase (AdR), that are fused into a single ORF using FMDV 2A nucleotide sequences.
Bovine CYP11A1 manifests 2beta- and 16beta-hydroxylase activity.
Data suggest that the upstream region of gene encoding CYP11A contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex.
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1).
Focimatrix may potentially regulate CYP11A1 expression, and the regulation of both could be important in ovarian follicular dominance.
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
Data show that a deletion of 20 amino acids comprising parts of the F-G loop results in an enzyme with a three-fold increased solubility, the highest solubility of a CYP11A1 variant obtained so far.
kinetic analysis of CYP11A1
Results describe the association of vitamin D3 with phospholipid vesicles and determine the kinetics of metabolism of vitamin D3 by P450scc in vesicles and in 2-hydroxypropyl-beta-cyclodextrin (cyclodextrin).
Results describe the membrane topology of CYPs 27A1 and 11A1.
We have shown, for the first time to our knowledge, the expression of CYP11A1 gene in the porcine endometrium and myometrium during early pregnancy and the oestrous cycle.
Leptin in elevated doses, by stimulatory effect on CYP11A1 and 17b-HSD protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.
Data suggest that gonadotropin-induced accumulation of P450scc mRNA results from increased transcription, and that this stimulation, at least in part, is protein synthesis-dependent.
Testicular expression of CYP11A1 is not solely responsible for the QTL influencing boar fat androstenone levels.
Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.
cholesterol side-chain cleavage enzyme, mitochondrial
, cytochrome P450 11A1
, cytochrome P-450 cholesterol side-chain cleavage enzyme
, Cholesterol desmolase
, Cytochrome P450 11A1
, Cytochrome P450(scc)
, cholesterol desmolase
, cytochrome P450(scc)
, cholesterol 20-22 desmolase
, cholesterol monooxygenase (side-chain cleaving)
, cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
, cytochrome P450C11A1
, steroid 20-22-lyase
, cholesterol side chain cleavage
, cytochrome P450 side-chain cleavage enzyme
, cytochrome P450, 11a, cholesterol side-chain cleavage
, cholesterol side-chain cleavage cytochrome P450
, cytochrome P450 11a cholesterol side chain cleavage
, cytochrome P450 subfamily 11A
, Cholesterol side-chain cleavage enzyme, mitochondrial
, cytochrome P450scc
, cytochrome P450 family 11 subfamily A polypeptide 1