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A gradually increasing number of spermatozoa and testis hypertrophy from 3 to 6 mpf were observed for testicular development in cytochrome P450 cyp17a1-deficient fish.
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
In vivo, clotrimazole induced a concentration-dependent increase of cyp17a1 gene expression and Cyp17-I protein synthesis in zebrafish testis.
Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus
the enzyme P450c17 seemed to be expressed in ovary and non-gonadal tissues including the brain, gill, liver and intestine
The immunolocalization of P450c17, detected in the ovaries of pregnant pigs and fetal porcine gonads, indicates the potential sites of androgen synthesis.
LH and insulin stimulate transcription of -976/+31 bp 5'-upstream cis-acting region of porcine CYP17 gene. Maximal transcriptional responsiveness requires proximal Sp1 and AP-2-like sequences -193 to -180 bp 5' upstream of transcriptional start site.
Synthesis of androstenone in pig testis is not directly affected by any polymorphisms in the coding region of the porcine CYP17 gene.
effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone
These results demonstrate the differential effects of two forms of CYB5 on the three activities of porcine CYP17A1 and show that CYB5B does not stimulate the andien-beta synthase activity of CYP17A1.
Study shows the expression of CYP17A1 gene was positively correlative with glioma pathological grades. Results reveal that CYP17A1 plays a major role in the progress of glioma.
The equilibrium dissociation constant (Kd) value of the CYB5A/CYP17A1 complex decreased by 5 times in the presence of progesterone (P4), which was due to a 10 times increase in the association rate constant (kon).
G162R substitution exhibits decreased CYP17A1 protein stability compared to WT with a near 70% reduction in protein levels as determined by immunoblot analysis
Dysfunctional LCs of men with SCOS show post-transcriptional deregulation of CYP17A1, with increased mRNA and decreased protein expression, which may be modulated by increased ITE2 levels.
The combined analysis of the polymorphisms PGR-CYP17A1-CYP19A1 suggests a gene-gene interaction in the susceptibility to endometriosis
The single nucleotide polymorphism rs11191548 near CYP17A1 is associated with high-density lipoprotein cholesterol and leptin in Chinese children. These findings provide evidence that HDL and leptin might mediate the process of CYP17A1 involved in hypertension.
- 34T>C polymorphism in CYP17A1 is associated with polycystic ovary syndrome.
We present one novel and one ultra rare gene variant with 17-OH deficiency, both described for the first time
identified a novel compound heterozygous CYP17A1 mutation His373Tyr (c.1117C>T) in a patient with 17alpha-hydroxylase/17,20-lyase deficiency.
the rs11191548 CYP17A1 gene mutation was associated with hypertension and the serum 25(OH) D levels in Han Chinese
No significant difference was observed in the RNA levels of CYP1A1 and SULT1A1 between the two groups. The frequency of expression of the CYP17 T/C variant tended to be higher and the A allele of COMT polymorphism together with down-regulation of its mRNA expression may be more frequent in Chinese women with idiopathic POI
T allele of rs743572 T polymorphism might predict high susceptibility to endometriosis, but it had no significant influence on characteristics and severity of endometriosis.
A polymorphism in the CYP17A1 gene was associated with the response to steroidogenesis inhibitors in Cushing's syndrome.
A single-point mutation at asparagine 202 in the active site pocket of CYP17A1, even when far from the heme, has profound effects on steroidogenic selectivity in androgen biosynthesis. In the mutant the 17alpha alcohol of OHPROG forms a H-bond with the proximal rather than terminal oxygen of the oxy-ferrous complex.When OHPREG was a substrate, the mutant was found to have weak H-bonding interaction with the proximal ox...
VT-464 reduces androgen receptor (AR) signaling more effectively than abiraterone in cultured PCa cells expressing T877A AR mutant
To our knowledge, this is the first study showing that the CYP17 T-34C and CYP19 T
the CYP17A1 polymorphisms could be a genetic risk factor for essential hypertension among the Yunnan Han Chinese population.
one CYP17A1 mutation (p.Arg362Cys) may share a common ancestry in Brazilian and present Spanish patients, while p.Trp406Arg may have arisen separately.
the CYP17CC genotype was significantly associated with developmental stuttering
A novel nonsense mutation in androgen receptor confers resistance to CYP17A1 inhibitor treatment in prostate cancer.
This study focused on the reaction of the bovine CYP17A1 enzyme with progesterone as a substrate. On the basis of a created homology model, active-site residues were identified and systematically mutated to alanine. In whole-cell biotransformations, the importance of the N202, R239, G297 and E305 residues for substrate conversion was confirmed.
BMP6 has a role in downregulating INSL3 and CYP17A1 and other proteins that modulate ovarian androgen production
By alignment analysis and sequencing, we detected that the g.329C>T SNP is a false positive polymorphism, which allows us to explain the inflated heterozygotic value.
The binding of SF-1 to the CYP17 and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.
Data suggest that the upstream region of gene encoding CYP17 contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex. [REVIEW]
the bovine genome contains three paralogous copies of the CYP17A1 gene, of which two (CYP17A1b and CYP17A1x) might be silenced by epigenetic modification (promoter methylation).
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone [P450c17]
Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
through mouse-to-human search and validation, we found that CYP17A1 is overexpressed in hepatocellular carcinomas and it has great potentiality as a noninvasive marker for hepatocellular carcinoma detection
Demonstration of the physiologic importance of cytochrome b5 activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.
TRalpha/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 transactivation on these promoters.
ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Data suggest that newly synthesized protein(s) are required for cAMP induction of CYP17 and 3-beta-HSD mRNA levels (but not of CYP11A mRNA levels). [REVIEW]
Data suggest that immune-activation of testicular interstitial macrophages may cause inhibition of P450c17 gene expression in Leydig cells.
Mamld1 enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3-related non-canonical Notch signaling
Fxr-/-Shp-/- mice exhibited cholestasis and liver injury as early as 3 weeks of age with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1)
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc, P450(17alpha) and 17beta-HSD in mice.
cAMP induces expression of Cyp17 by a PKA-mediated mechanism which is inhibited by MIS signal transduction
CYP17, in addition to its 17alpha-hydroxylase/17,20-lyase activity, critical in androgen formation, also expresses a secondary activity, squalene monooxygenase (epoxidase).
CYP17 deletion causes infertility in male.
These results implicate Src tyrosine kinase in the regulation of CYP17 and thecal androgen secretion.
P450c17 is expressed in mouse embryonic stem cells, its expression increases upon differentiation to an early embryonic endoderm lineage.
Results suggest that in the adult mouse brain, dehydroepiandrosterone is formed via a Fe(2+)-sensitive cytochrome P450 17alpha-hydroxylase/17, 20 lyase-independent pathway.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
cytochrome P450 17A1
, steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450c17
, cytochrome P450-C17
, cytochrome P450 XVIIA1
, steroid 17-alpha-monooxygenase
, steroidogenic cytochrome P450 17-hydroxylase/lyase
, Cytochrome P450 17A1
, Steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450 steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450, family 17, subfamily A, polypeptide 1
, 17-alpha-hydroxyprogesterone aldolase
, 17-alpha-hydroxylase cytochrome P450
, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
, cytochrome p450 XVIIA1
, cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase
, cytochrome P450, subfamily XVII
, steroid 17-alpha-hydroxylase
, cytochrome P450, 17
, cytochrome P450, 17a1
, steroid 17-alpha hydroxylase
, Cytochrome P450, subfamily XVII
, cytochrome P450, subfamily 17
, cytochrome P450 17 alpha-hydroxylase