MPL Produits
(Myeloproliferative Leukemia Virus Oncogene (MPL))
Catégories
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
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Catégories MPL en vedette
MPL Anticorps
High quality antibodies with extensive validation data.
MPL Kits ELISA
Reliable ELISA kits for a wide range of species.
MPL Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MPL recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
N° du produit
ABIN7440170
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (2)
- (3)
N° du produit
ABIN969542
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS, IHC, ICC, Neut
Validations
- (4)
N° du produit
ABIN5611182
Quantité
0.1 mg
Fiche technique
Fiche technique
MPL recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957947
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN1117542
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN5510636
Quantité
96 tests
Fiche technique
Fiche technique
MPL recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7275276
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (3)
N° du produit
ABIN3113551
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7275277
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MPL
: "Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis." dans: Leukemia, (2017) (PubMed).: "Aerobic exercise in humans mobilizes HSCs in an intensity-dependent manner." dans: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 122, Issue 1, pp. 182-190, (2017) (PubMed).
: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." dans: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).
: "Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity." dans: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11781-91, (2009) (PubMed).
: "Genetic mutations associated with cigarette smoking in pancreatic cancer." dans: Cancer research, Vol. 69, Issue 8, pp. 3681-8, (2009) (PubMed).
: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." dans: Blood, Vol. 92, Issue 6, pp. 1981-8, (1998) (PubMed).
: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." dans: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, (1998) (PubMed).
: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." dans: Blood, Vol. 88, Issue 6, pp. 2026-32, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à MPL
MPL proto-oncogene, thrombopoietin receptor (MPL), myeloproliferative leukemia virus oncogene (Mpl), MPL proto-oncogene, thrombopoietin receptor (Mpl), MPL proto-oncogene, thrombopoietin receptor (mpl), C-MPL, c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, MPL, mpll, MPLV, THCYT2, TPO-R, TPOR, tpor, tpor.bProtein level used designations for MPL
- TPO-R
- myeloproliferative leukemia protein
- proto-oncogene c-Mpl
- thrombopoietin receptor
- myeloproliferative leukemia virus oncogene
- thrombopoietin receptor-like
- cytokine receptor
- myeloproliferative leukemia virus oncogene, like
- thrombopoietin receptor c-mpl
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