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MTA1 Produits

(Metastasis Associated 1 (MTA1))

Catégories

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

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Catégories MTA1 en vedette

MTA1 Anticorps

High quality antibodies with extensive validation data.

MTA1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MTA1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (7)
N° du produit ABIN522561
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (6)
N° du produit ABIN563943
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (5)
N° du produit ABIN7193370
Quantité 0.1 mg
Fiche technique Fiche technique

MTA1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6957781
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN5648083
Quantité 96 tests
Fiche technique Fiche technique

MTA1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1311515
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1311513
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1311512
Quantité 25 μg
Fiche technique Fiche technique

Dernières publications sur nos produits MTA1

Reddy, Pakala, Molli, Sahni, Karanam, Mudvari, Kumar: "Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function." dans: The Journal of biological chemistry, Vol. 287, Issue 33, pp. 27843-50, (2012) (PubMed).

Ghanta, Pakala, Reddy, Li, Nair, Kumar: "MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response." dans: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7132-8, (2011) (PubMed).

Pakala, Singh, Reddy, Ohshiro, Li, Mishra, Kumar: "TGF-β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells." dans: Oncogene, Vol. 30, Issue 19, pp. 2230-41, (2011) (PubMed).

Zhu, Guo, Li, Ding, Chen: "Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer." dans: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1159-66, (2010) (PubMed).

Van Rechem, Boulay, Pinte, Stankovic-Valentin, Guérardel, Leprince: "Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells." dans: Molecular and cellular biology, Vol. 30, Issue 16, pp. 4045-59, (2010) (PubMed).

Yang, Liu, Li: "[Expression of Mta-1 and VEGF and their correlation in the endometrial cancer]." dans: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, Vol. 26, Issue 7, pp. 682-4, (2010) (PubMed).

Li, Ohshiro, Khan, Kumar: "Requirement of MTA1 in ATR-mediated DNA damage checkpoint function." dans: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 19802-12, (2010) (PubMed).

Li, Pakala, Reddy, Ohshiro, Peng, Lian, Fu, Kumar: "Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway." dans: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 10044-52, (2010) (PubMed).

Pakala, Reddy, Bui-Nguyen, Rangparia, Bommana, Kumar: "MTA1 coregulator regulates LPS response via MyD88-dependent signaling." dans: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 32787-92, (2010) (PubMed).

Li, Divijendra Natha Reddy, Pakala, Wu, Zhang, Rayala, Kumar: "MTA1 coregulator regulates p53 stability and function." dans: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 34545-52, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à MTA1

metastasis associated 1 (MTA1), metastasis associated 1 (Mta1), metastasis associated 1 L homeolog (mta1.L), Tex22

Protein level used designations for MTA1

  • metastasis associated gene 1 protein
  • metastasis-associated protein MTA1
  • testis expressed 22
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