Nicastrin Produits
(Nicastrin (NCSTN))
Catégories
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Catégories Nicastrin en vedette
Nicastrin Anticorps
High quality antibodies with extensive validation data.
Nicastrin Kits ELISA
Reliable ELISA kits for a wide range of species.
Nicastrin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Nicastrin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
N° du produit
ABIN565059
Quantité
50 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (3)
N° du produit
ABIN7268905
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (1)
- (1)
N° du produit
ABIN761801
Quantité
100 μL
Fiche technique
Fiche technique
Nicastrin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730247
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4883865
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1145111
Quantité
96 tests
Fiche technique
Fiche technique
Nicastrin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1312150
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1312152
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7320108
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Nicastrin
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." dans: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).
: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." dans: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." dans: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." dans: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." dans: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." dans: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à Nicastrin
nicastrin (NCSTN), nicastrin (nct), nicastrin (ncstn), nicastrin (CpipJ_CPIJ001617), nicastrin (Ncstn), Nicastrin (aph-2), 9430068N19Rik, AA727311, agro, APH2, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, Nic, nic, S5A, ST96BProtein level used designations for Nicastrin
- CG7012-PA
- CG7012-PC
- CG7012-PD
- CG7012-PE
- agoraphobic
- dNicastrin
- nct-PA
- nct-PC
- nct-PD
- nct-PE
- nicastrin
- ATAG1874
- anterior pharynx-defective 2
- membrane protein
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