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NUP98 Produits

(Nucleoporin 98kDa (NUP98))

Catégories

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described. [provided by RefSeq, May 2010].

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Catégories NUP98 en vedette

NUP98 Anticorps

High quality antibodies with extensive validation data.

NUP98 Kits ELISA

Reliable ELISA kits for a wide range of species.

NUP98 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

NUP98 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Application WB, ELISA, IF, ICC, DB
Validations
  • (2)
  • (14)
N° du produit ABIN2452066
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena
Application WB, IF
Validations
  • (2)
  • (8)
N° du produit ABIN2452065
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena
Application WB, IF
Validations
  • (2)
  • (8)
N° du produit ABIN2452064
Quantité 100 μg
Fiche technique Fiche technique

NUP98 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1116273
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN512355
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN511450
Quantité 96 tests
Fiche technique Fiche technique

NUP98 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1313248
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1313246
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3094287
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits NUP98

Blasius, Takao, Verhey: "NPHP proteins are binding partners of nucleoporins at the base of the primary cilium." dans: PLoS ONE, Vol. 14, Issue 9, pp. e0222924, (2019) (PubMed).

Lee, Singh, Tisdale, Abdel-Wahab, Leslie, Mayr: "Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia." dans: Nature, Vol. 561, Issue 7721, pp. 127-131, (2018) (PubMed).

McCloskey, Ibarra, Hetzer: "Tpr regulates the total number of nuclear pore complexes per cell nucleus." dans: Genes & development, Vol. 32, Issue 19-20, pp. 1321-1331, (2018) (PubMed).

Franks, Benner, Narvaiza, Marchetto, Young, Malik, Gage, Hetzer: "Evolution of a transcriptional regulator from a transmembrane nucleoporin." dans: Genes & development, Vol. 30, Issue 10, pp. 1155-71, (2016) (PubMed).

Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." dans: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).

Iwamoto, Asakawa, Hiraoka, Haraguchi: "Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 661-9, (2010) (PubMed).

Fukuhara, Ozaki, Shikata, Katahira, Yoneda, Ogino, Tachibana: "Specific monoclonal antibody against the nuclear pore complex protein, nup98." dans: Hybridoma (2005), Vol. 24, Issue 5, pp. 244-7, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à NUP98

Nucleoporin 98-96kD (Nup98-96), nuclear pore complex protein Nup98-Nup96 (LOC408335), nucleoporin 98 (NUP98), nuclear pore complex protein Nup98-Nup96 (LOC587580), nucleoporin 98kDa (NUP98), nucleoporin 98 (Nup98), nucleoporin 98 (nup98), nucleoporin 98 L homeolog (nup98.L), 4732457F17, ADIR2, AI849286, CG10198, CG10201, Dmel\\CG10198, GB12688, im:7151238, l(3)95BCd, Nup-98, Nup 96, Nup96, NUP96, Nup 98, Nup98, NUP98, nup98-96, Nup98-Nup96, Nup98/96, nup145, NUP196, zgc:63593, zgc:113968

Protein level used designations for NUP98

  • CG10198-PA
  • CG10198-PC
  • CG10198-PD
  • Nup98
  • Nup98-96-PA
  • Nup98-96-PC
  • Nup98-96-PD
  • nucleoporin 98
  • nucleoporin 98-96
  • nucleoporin98-96
  • nucleoporin 98kD
  • nucleoporin 98kDa
  • nuclear pore complex protein Nup98-Nup96-like
  • nuclear pore complex protein Nup98-Nup96
  • 98 kDa nucleoporin
  • nuclear pore complex protein Nup98
  • nucleoporin Nup98
  • GLFG-repeat containing nucleoporin
  • Nup98-Nup96
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