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ESR1 inhibits the expression of Pitx2 (Montrer PITX2 Protéines) gene by binding to a left side-specific enhancer region in Pitx2 (Montrer PITX2 Protéines) gene and recruiting histone deacetylase 1 (Montrer HDAC1 Protéines) to this region, leading to the suppression of Pitx2 (Montrer PITX2 Protéines) gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
DNA methylation (Montrer HELLS Protéines) and transcriptome aberrations mediated by ERalpha in mouse seminal vesicles following developmental DES (Montrer DES Protéines) exposure.
This novel transgenic mouse line will be a useful animal model for lineage-tracing Esr1-expressing cells, selective gene ablation in the Esr1-lineage cells and for generating global Esr1 knockout mice.
Data (including data from studies in transgenic mice) suggest that Esr1 signaling promotes activation of Pp2a; here, central activation of Pp2a during estrogen replacement therapy is involved in prevention of menopause-induced obesity and glucose intolerance (that is, induced by lack of membrane-initiated Esr1 signaling). (Esr1 = estrogen receptor 1; Pp2a = protein phosphatase 2A)
Results show that membrane initiated ERalpha signaling is important for the estrogen response in adult female mice in vivo in a tissue-dependent manner, and that membrane ERalpha signaling is crucial for the estrogen response in trabecular bone in the axial skeleton.
Results show that ERalpha activation might constitute one of the neural substrate that is involved involved in the facilitative mechanisms to restore the sexual olfactory preferences of sexually naive Tph2 (Montrer TPH2 Protéines)-/- female mice.
Study found that estrogen receptor alpha (ERalpha) was expressed in the motoneurons of lumbar ventral horn. ERalpha and ERbeta (Montrer ESR2 Protéines) were mainly localized in the nuclei of motoneurons with less immunoreactivity in the cytoplasm.
suggest miR (Montrer MLXIP Protéines)-181a inhibition enhances E2-mediated stroke protection in females in part by augmenting ERalpha production
nuclear Shp2 (Montrer PTPN11 Protéines), rather than cytosolic Shp2 (Montrer PTPN11 Protéines), promotes the ERalpha transcription activity. This function is achieved by enhancing the Src kinase (Montrer CSK Protéines)-mediated ERalpha tyrosine phosphorylation, which facilitates ERalpha binding to Pgr (Montrer PGR Protéines) promoter in an ERK (Montrer EPHB2 Protéines)-independent manner in periimplantation uteri.
ERalpha masculinizes GABAergic neurons that gate the display of male-typical behaviors.
The administration of ICI182,780, which is an agonist of G-protein coupled estrogen receptor (GPER (Montrer GPER Protéines)) and an antagonist of ERa and ERb (Montrer ESR2 Protéines), did not result in protection; however, ICI182,780 significantly blocked EDC-mediated cardioprotection, indicating participation of ERalpha and/or ERbeta (Montrer ESR2 Protéines)
The presence of a single isoform of ESR1 (66kDa (Montrer SF3A2 Protéines)) and ESR2 (Montrer ESR2 Protéines) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER (Montrer GPER Protéines) in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor (Montrer PGR Protéines) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
Results showed that the effects of FSHb (Montrer FSHB Protéines), ESR, and PRLR (Montrer PRLR Protéines) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (Montrer COX8A Protéines) and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (Montrer ESR2 Protéines) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (Montrer ESR2 Protéines)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (Montrer ESR2 Protéines) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta (Montrer ESR2 Protéines) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (Montrer ESR2 Protéines) after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (Montrer ESR2 Protéines), ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (Montrer ESR2 Protéines) and ERbeta-B and induces apoptosis in an ER-independent manner
The mRNA expression of ER-alpha and ER-beta (Montrer ESR2 Protéines) in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor (Montrer PGR Protéines) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta (Montrer ESR2 Protéines) is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase (Montrer CYP19A1 Protéines) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta (Montrer ESR2 Protéines) and PR in bovine oviducts at different cycle stages in vivo
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (Montrer SNRPB Protéines)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (Montrer TNF Protéines) and IFNgamma regulate ERalpha and ERbeta (Montrer ESR2 Protéines) mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
verexpression of COPS5 (Montrer COPS5 Protéines), through its isopeptidase activity, leads to ubiquitination and proteasome-mediated degradation of NCoR (Montrer NCOR1 Protéines), a key corepressor for ERalpha and tamoxifen-mediated suppression of ERalpha target genes.
ESR alpha PvuII and XbaI polymorphisms have no association with ; systemic lupus erythematosus. The combination of the TC/AA and CC/GG genotypes were associated with SLE susceptibility.
Estrogen receptor (ER) and progesterone receptor (PR (Montrer PGR Protéines)) expression in endometrial carcinoma (EC) were significantly higher than those in the paracarcinoma tissue and control.
ESR1 promoter methylation was an independent risk factor and had a high value to predict 28-day mortality from acute-on-chronic hepatitis B liver failure
by analyzing different estrogen receptor-alpha(ER-a)-positive and ER-a-negative breast cancer cell lines, we defined the role of CCN5 (Montrer WISP2 Protéines) in the leptin (Montrer LEP Protéines)-mediated regulation of growth and invasive capacity.
This study identified ESR1 as a direct target of miR (Montrer MLXIP Protéines)-301a-3p.
Authors report for the first time the presence of ESR1 methylation in plasma ctDNA of patients with HGSC. The agreement between ESR1 methylation in primary tumors and paired ctDNA is statistically significant.
the P2X7R (Montrer P2RX7 Protéines) rs3751143 and ER-alpha PvuII two-locus interaction confers a significantly high susceptibility to osteoporosis in Chinese postmenopausal women.
ERalpha and ERbeta (Montrer ESR2 Protéines) mRNA expression was significantly higher (p < 0.05) in tumour tissues relative to their paired normal mucosa and correlated inversely with survival outcome
High ESR1 expression is associated with Papillary Thyroid Carcinoma.
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor