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anti-Interleukin 1 alpha (IL1A) antibody pair

ELISA Reactivité: Souris ELISA unconjugated Hôte: Lapin Polyclonal
N° du produit ABIN1305225
  • Antigène Tous les produits IL1A
    IL1A (Interleukin 1 alpha (IL1A))
    Reactivité
    Souris
    Hôte
    • 5
    • 4
    Lapin
    Clonalité
    Polyclonal
    Type de méthode
    Sandwich ELISA
    Gamme de detection
    15.6-2000 pg/mL
    Seuil minimal de détection
    15.6 pg/mL
    Application
    ELISA
    Specificité
    Detects mouse IL-1alpha.
    Aucune reactivité croisée
    Humain
    Réactivité croisée (Details)
    Does not detect human IL-1alpha or mouse IL-1beta.
    Sensibilité
    10 pg/mL
    Ingrédients
    1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μg) [COAT] 1 vial detection antibody (30μg) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
  • Restrictions
    For Research Use only
  • Concentration
    Lot specific
    Stock
    -20 °C
    Stockage commentaire
    Short Term Storage: -20°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Antigène
    IL1A (Interleukin 1 alpha (IL1A))
    Autre désignation
    IL-1alpha (IL1A Produits)
    Synonymes
    IL-1A Matched Antibody Pair, IL1 Matched Antibody Pair, IL1-ALPHA Matched Antibody Pair, IL1F1 Matched Antibody Pair, IL-6 Matched Antibody Pair, Il-1a Matched Antibody Pair, IL-1 alpha Matched Antibody Pair, IL-1alpha Matched Antibody Pair, L1A Matched Antibody Pair, interleukin 1 alpha Matched Antibody Pair, interleukin 6 Matched Antibody Pair, IL1A Matched Antibody Pair, IL6 Matched Antibody Pair, Il1a Matched Antibody Pair
    Sujet
    The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
    UniProt
    P01582
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