(Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase\; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008].
Koivunen, Helaakoski, Annunen, Veijola, Räisänen, Pihlajaniemi, Kivirikko: "ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase." dans: The Biochemical journal, Vol. 316 ( Pt 2), pp. 599-605, (1996) (PubMed).
Bourdi, Demady, Martin, Jabbour, Martin, George, Pohl: "cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase." dans: Archives of biochemistry and biophysics, Vol. 323, Issue 2, pp. 397-403, (1995) (PubMed).
Hirano, Shibasaki, Kato, Sakai, Tanaka, Nishida, Yazaki, Takenawa, Hirai: "Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha." dans: Biochemical and biophysical research communications, Vol. 204, Issue 1, pp. 375-82, (1994) (PubMed).
Pseudonymes pour PDIA3 Protéines
protein disulfide isomerase family A member 3 (PDIA3) Protéines protein disulfide-isomerase A3 (Tsp_10062) Protéines protein disulfide isomerase associated 3 (Pdia3) Protéines protein disulfide isomerase family A, member 3 (Pdia3) Protéines protein disulfide isomerase family A member 3 (Pdia3) Protéines protein disulfide isomerase family A, member 3 (pdia3) Protéines protein disulfide isomerase family A member 3 S homeolog (pdia3.S) Protéines 1 Protéines 25D3-membrane-associated Protéines 58kDa Protéines ER60 Protéines Erp Protéines ERp57 Protéines erp57 Protéines ERp60 Protéines ERp61 Protéines grp-58 Protéines GRP57 Protéines GRP58 Protéines Grp58 Protéines grp58 Protéines HsT17083 Protéines P58 Protéines PDI Protéines PDI-Q2 Protéines pdia3 Protéines PI-PLC Protéines Plca Protéines PLC[a] Protéines sb:cb825 Protéines