Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (C-Term) Peptide
LDLRAP1
Reactivité: Humain, Souris
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits LDLRAP1
- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
- Protein Region
- C-Term
- Origine
- Humain, Souris
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- APLSTVSANT NNVDETPRPQ VLGNNSVVWE LDDGLDEAFS RLAQSRTNPQ
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Ldlrap1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
- Synonymes
- ARH Peptide, ARH1 Peptide, ARH2 Peptide, FHCB1 Peptide, FHCB2 Peptide, AA691260 Peptide, Arh Peptide, Arh1 Peptide, RGD1563417 Peptide, arh Peptide, arh1 Peptide, arh2 Peptide, fhcb1 Peptide, fhcb2 Peptide, xptb Peptide, LDLRAP1 Peptide, ldlrap1 Peptide, sb:cb50 Peptide, zgc:56121 Peptide, zgc:158745 Peptide, low density lipoprotein receptor adaptor protein 1 Peptide, low density lipoprotein receptor adaptor protein 1 L homeolog Peptide, low density lipoprotein receptor adaptor protein 1 S homeolog Peptide, low density lipoprotein receptor adaptor protein 1a Peptide, low density lipoprotein receptor adaptor protein 1b Peptide, LDLRAP1 Peptide, Ldlrap1 Peptide, ldlrap1 Peptide, ldlrap1.L Peptide, ldlrap1.S Peptide, ldlrap1a Peptide, ldlrap1b Peptide
- Sujet
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Ldlrap1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). It may be required for LDL binding and internalization but not for receptor clustering in coated pits. It may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. Ldlrap1 may also be involved in the internalization of other LDLR family members. Ldlrap1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
Alias Symbols: AA691260, ARH2, Arh, Arh1, FHCB1, FHCB2
Protein Size: 264 - Poids moléculaire
- 29 kDa
- ID gène
- 100017
- NCBI Accession
- NM_145554, NP_663529
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