NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (C-Term) Peptide
NAE1
Reactivité: Souris, Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN1541277
150,78 €
Plus frais de livraison 40,00 € et TVA
100 μg
Destination:
France
Envoi sous 15 à 22 jours ouvrables
Aperçu rapide pour NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (C-Term) Peptide (ABIN1541277)
Antigène
NAE1
(NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
Origine
Souris, Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Séquence
- ARALKEFVAK EGQGNLPVRG TIPDMIADSN KYIKLQNVYR EKAKKDAAAV
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Nae1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
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Sujet
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Nae1 is a regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Alias Symbols: 59 kDa, Appbp1
Protein Size: 534 -
Poids moléculaire
- 60 kDa
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ID gène
- 234664
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NCBI Accession
- NM_144931, NP_659180
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UniProt
- Q8VBW6
Antigène
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