TNF Receptor-Associated Factor 6 (TRAF6) (C-Term) Peptide
TRAF6
Reactivité: Humain
Hôte: Synthetic
BP, WB
-
- Antigène Tous les produits TRAF6
- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
- Protein Region
- C-Term
- Origine
- Humain
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TRAF6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Antigène
- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
- Synonymes
- MGC:3310 Peptide, RNF85 Peptide, 2310003F17Rik Peptide, AI851288 Peptide, C630032O20Rik Peptide, rnf85 Peptide, traf6 Peptide, xtraf6 Peptide, CG10961 Peptide, DTRAF2 Peptide, Dmel\\CG10961 Peptide, TRAF Peptide, TRAF2 Peptide, TRAF6 Peptide, Traf2 Peptide, dTRAF2 Peptide, dTRAF6 Peptide, dTraf2 Peptide, dtraf2 Peptide, GB10539 Peptide, fi15f02 Peptide, wu:fi15f02 Peptide, zgc:63704 Peptide, TNF receptor associated factor 6 Peptide, TNF receptor-associated factor 6 Peptide, TNF receptor associated factor 6 L homeolog Peptide, TNF-receptor-associated factor 6 Peptide, TNF receptor associated factor 6 S homeolog Peptide, TRAF6 Peptide, Traf6 Peptide, traf6.L Peptide, traf6 Peptide, LOC551819 Peptide, traf6.S Peptide
- Sujet
-
TRAF6 is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. It may be essential for the formation of functional osteoclasts. It seems to also play a role in dendritic cells (DCs) maturation and/or activation. It represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. It regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.
Alias Symbols: MGC:3310, RNF85
Protein Size: 522 - Poids moléculaire
- 57 kDa
- ID gène
- 7189
- NCBI Accession
- NM_004620, NP_004611
- UniProt
- Q9Y4K3
-
Vous êtes ici:
