Dynactin 1 (DCTN1) (Middle Region) Peptide
DCTN1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5511123
Aperçu rapide pour Dynactin 1 (DCTN1) (Middle Region) Peptide (ABIN5511123)
Antigène
Dynactin 1 (DCTN1)
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Séquence
- PYECLRQSCN ILISTMNKLA TAMQEGEYDA ERPPSKPPPV ELRAAALRAE
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- DCTN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Dynactin 1 (DCTN1) peptide
DCTN1 Reactivité: Humain, Souris, Rat Hôte: Synthetic BP, Imm
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Dynactin 1 (DCTN1)
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Sujet
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This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
Alias Symbols: P135, DP-150, DAP-150
Protein Size: 1278 -
ID gène
- 1639
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NCBI Accession
- NM_001135040, NP_001128512
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UniProt
- Q14203
Antigène
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